Structure-based design of δ-lactones for new antifungal drug development: susceptibility, mechanism of action, and toxicity

Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens

“…The rupture of the cell could be related to the effect of the molecule on the cell wall and consequent death of the microorganism (fungicidal effect). The same morphological damage in fungi cells was recently observed in related studies using SEM, after treating the strains with a variety of others organic compounds (Dalla Lana et al, 2015, Dalla Lana et al, 2018, Dalla Lana et al, 2019, Batista et al, 2017).…”