Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice

Yu-hui, YE; Ji, Desheng; You, Lijun; Zhou, Lin; Zhao, Zhengang; Brennan, Charles S.

doi:10.1016/j.jff.2018.01.025

Cited by 79 publications

(40 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, glucuronic acid content significantly decreased with 0.4 molar ratio to glucose, which indicated an optimized purity of fucoidan. Glucuronic acid content is much lower than those previous reported findings, perhaps due to the procedure for calcium-alginate precipitation [32,33]. In addition, it was found that cSFP is composed of glucose, xylose, rhamnose, and mannose.…”

Section: Quantitative Analysis Of Monosaccharide Componentscontrasting

confidence: 65%

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Dai

Zhou

Jiang

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

Contrast-induced nephropathy (CIN) is a common complication in patients with coronary arteriography, and oxidative stress is involved in the CIN pathogenesis. Sargassum fusiforme (SF) is a brown seaweed with medicinal value, and its polysaccharides have good antioxidant activity. In this study, the crude polysaccharides (cSFP-C) were extracted by cold water, precipitated by ethanol, purified by CaCl2, and detected with high contents of sulfate radical and fucose. cSFP-C is composed of glucose, glucuronic acid, xylose, rhamnose, mannose, galactose, and fucose with a molar ratio of 1.0 : 0.4 : 5.6 : 1.2 : 1.7 : 12.3 : 56.1. The cSFP-C has the typical absorption of polysaccharides. Antioxidation assays in vitro showed that cSFP-C exhibited superoxide radical scavenging activity which was better than the hot water-extracted crude polysaccharides (cSFP-H). 20 rats were divided into 4 groups (n=5): sham group; CIN group; CIN+cSFP-C group, and cSFP-C group. The CIN+cSFP-C group and cSFP-C group were pretreated intragastrically with cSFP-C at a dose of 9.45 g/kg twice daily for 5 consecutive days. Then, the CIN group and CIN+cSFP-C group were given indomethacin to develop CIN. The in vivo results showed that cSFP-C could decrease blood creatinine and urea nitrogen, inhibiting pathological injury in the renal tissues. The MDA content of renal tissues was decreased, while the activity of SOD was increased. The crude sulfated polysaccharides extracted from S. fusiforme have a renoprotective effect on oxidative stress to alleviate the kidney injury in CIN rats.

show abstract

Section: Quantitative Analysis Of Monosaccharide Componentscontrasting

confidence: 65%

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Dai

Zhou

Jiang

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…Polysaccharide is a component of biological organisms and an important biologically active substance that possesses multiple functions, such as antioxidant (Dammak et al, ; Ji et al, ; Ye et al, ), anti‐obesity (Chang et al, ) and immunomodulating properties (Du J et al, ; Jin et al, ; Yu et al, ). The human body lacks carbohydrate active enzymes that can utilize polysaccharides directly.…”

Section: Introductionmentioning

confidence: 99%

A novel polysaccharide isolated from Flammulina velutipes, characterization, macrophage immunomodulatory activities and its impact on gut microbiota in rats

Wang

et al. 2020

Animal Physiology Nutrition

View full text Add to dashboard Cite

The structural characteristics of a novel Flammulina velutipes polysaccharide (FVP2) were explored in this study. Besides, immunomodulatory activities of FVP2 on RAW 264.7 cell and its impact on gut microbiota in rats were investigated. FVP2 has a molecular weight of 18.3 kD, and its main components include galactose (19.96%), glucose (60.66%) and mannose (19.38%). By NMR analysis, the main‐chain structure consisted of (1 → 3)‐linked‐β‐D‐Gal, (1 → 6) ‐linked‐β‐D‐Gal, (1 → 6)‐linked‐α‐D‐Glc and (1 → 3,6)‐linked‐α‐D‐Man was identified. Results of the in vitro assays on RAW 264.7 murine macrophage cells showed FVP2 could significantly up‐regulate the expression of NO, TNF‐α and IL‐6. FVP2 was intragastrically administered to rats for 2 weeks. Compared with the control group, two caecal short‐chain fatty acids (SCFAs) concentration (isobutyric acid and butyric acid) and the abundance of beneficial microbiota of the FVP2‐treated group were significantly increased (p < .05) respectively. The results demonstrated that FVP2 could effectively enhance the level of butyric acid and increase beneficial gut microbiota, which could improve the intestinal barrier function and maintain the intestinal mucosal integrity, suggesting that FVP2 could potentially be an immunomodulators or a functional food to promote intestinal health.

show abstract

“…Results showed that the extracted SFP alleviated UVB-triggered oxidative stress by increasing the catalytic activities of catalase and superoxide dismutase and diminishing the malondialdehyde and ROS levels. SFP treatment also suppressed the levels of MMP-1 and 9 [89]. It was found that the administration of different dose levels of SFP significantly reduced the thickness of both dermis and epidermis and attenuated the sebaceous hyperplasia.…”

Section: Ultraviolet (Uv) Protectant Potentialmentioning

confidence: 90%

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Bilal

Iqbal

2019

Marine Drugs

View full text Add to dashboard Cite

Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.

show abstract

Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice

Cited by 79 publications

References 54 publications

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

A novel polysaccharide isolated from Flammulina velutipes, characterization, macrophage immunomodulatory activities and its impact on gut microbiota in rats

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Contact Info

Product

Resources

About