Structural Organization of Themagnetic Part of Smart Material Based on Nanoparticles of Iron or Magnetite in Pores of Mcm-41 Mesoporous Silica for Target Drug Delivery

Abstract

The important stage of the development of smart material for the target drug delivery is the construction of the magnetic part of this material, including mesoporous silica and magnetic nanoparticles (Fe3O4or Fe0). Such a systemwill allow carry outmagnetic decapsulation (excretion) of drug from smart material using the magnetic field of a given value in the right place of the body. The paper considers the features of synthesis mesoporous silica MCM-41 with various pore diameter (33-51 Å) and synthesis of superparamagnetic nanoparticles of magnetite or metallic iron in the pores of mesoporous silica. The dependence of magnetic properties of nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 from the pore diameters of MCM-41 templates is studied. It was found that the matrix has a decisive influence on the content of iron or magnetite nanoparticles. The saturation magnetization of the material increases with increasing pore size of the mesoporous matrix. Nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 exhibit superparamagnetism, that allows them to be used as a magnetic material for targeted drug delivery.

Progress in magnetic Fe3O4nanomaterials in magnetic resonance imaging

“…Effectively, the low r 2 and r 1 values were 13 and 0.3 mM −1 s −1 , respectively, and final r 2 /r 1 ratio was 39, which was deemed acceptable against other reported MNPs [142]. This was mainly because of the ideal spatial structure of mesoporous silica, which could make protons pass through smoothly, thus producing resonance signal; however, because of the influence of more coating layer and other metals, the resonance signal was relatively weakened [141]. The fluorescence emission of RAM was not completely quenched, and the intensity of the fluorescence increased with the increase in concentration, which showed excellent optical tracking.…”

“…After adjusting the pH with sodium hydroxide, TEOS was added, and the magnetic ferric oxide coated with mesoporous SiO 2 (Mag 320@MS) was obtained by electrostatic attraction. Mag 320@MS was emulsified by adding paraffin; after centrifugation and dilution with methanol, Mag 320@MS was reacted with (3-mercaptopropyl)trimethoxysilane, and the product was stirred and compounded with the prepared Au nanoparticles [141] to obtain Janus Au-Magnetic@MS NPs (Janus Au-Mag 320@MS). Catalyzed by NHS and EDAC, Alexa Fluor 647 Hydrazide was modified to Janus Au-Mag 320@MS, then cRGD was modified on the surface in a phosphate buffer by covalently linking, and finally, the fluorescent material was modified on the Janus NPs (RAM, the overall size was 163 ± 2.8 nm).…”