Dissolving microneedles for alopecia treatment

Xiang, Hong; Xu, Sheng; Zhang, Wei-Wei; Xue, Xinyue; Li, Yixuan; Lv, Ying; Chen, Jing; Miao, Xiao

doi:10.1016/j.colsurfb.2023.113475

Cited by 7 publications

(3 citation statements)

References 77 publications

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“…This simple preparation of microparticle-loaded MNs localized amphotericin B inside the skin for a week for treatment of cutaneous fungal infections [ 29 ]. Moreover, the combination of microparticles such as liposomes with MN delivery systems also greatly improves bioavailability and particle stability in targeted delivery of drugs for the treatment of alopecia [ 30 ].…”

Section: Design Strategies Of Long-acting Polymeric Microneedlesmentioning

confidence: 99%

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Meng,

Qiao,

Xin

et al. 2024

J. pharm. pharm. sci.

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Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this technology to be an alternative to hypodermic needles. MNs can penetrate the stratum corneum and deliver active ingredients to the body through the dermal tissue in a controlled and sustained release. Long-acting polymeric MNs can reduce administration frequency to improve patient compliance and therapeutic outcomes, especially in the management of chronic diseases. In addition, long-acting MNs could avoid gastrointestinal reactions and reduce side effects, which has potential value for clinical application. In this paper, advances in design strategies and applications of long-acting polymeric MNs are reviewed. We also discuss the challenges in scale manufacture and regulations of polymeric MN systems. These two aspects will accelerate the effective clinical translation of MN products.

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Section: Design Strategies Of Long-acting Polymeric Microneedlesmentioning

confidence: 99%

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Meng,

Qiao,

Xin

et al. 2024

J. pharm. pharm. sci.

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“…Based on the drug types and administration methods, researchers have developed various types of microneedles, including solid microneedles, coated microneedles, hollow microneedles, dissolving microneedles, and hydrogel microneedles (HMNs) . The structures of these microneedles and their mechanisms of drug release or ISF extraction (HMNs only) are illustrated in Figure .…”

Section: Introductionmentioning

confidence: 99%

“…17 (4) The needle tips of microneedles can breach bacterial biofilms, facilitating the release of antimicrobial drugs into the interior of the biofilm through the interstitial fluid (ISF) at the wound site. 18 Based on the drug types and administration methods, researchers have developed various types of microneedles, including solid microneedles, 19 coated microneedles, 20 hollow microneedles, 21 dissolving microneedles, 22 and hydrogel microneedles (HMNs). 23 The structures of these microneedles and their mechanisms of drug release or ISF extraction (HMNs only) are illustrated in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Hydrogel Microneedles in Wound Management

Ji,

Zhan,

Qiu

et al. 2024

ACS Biomater. Sci. Eng.

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Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable drug delivery. As a type of polymer microneedle with a threedimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility and biodegradability and encapsulate various therapeutic drugs while maintaining drug activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing and have demonstrated favorable therapeutic effects. Although there are reviews about HMNs, few of them focus on wound management. Herein, we present a comprehensive overview of the design and preparation methods of HMNs, with a particular emphasis on their application status in wound healing, including acute wound healing, infected wound healing, diabetic wound healing, and scarless wound healing. Finally, we examine the advantages and limitations of HMNs in wound management and provide suggestions for future research directions.

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