Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications

Lee, Yeji; Phat, Chanvorleak; Hong, Soon Cheol

doi:10.1016/j.peptides.2017.06.002

Cited by 86 publications

(59 citation statements)

References 76 publications

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“…It is worth mentioning that many fungal cyclic peptides have been isolated from plant endophytic and marine-derived fungi, which indicates that plant endophytic and marine-drived fungi are mines of biologically active natural products [ 222 , 223 , 224 , 225 , 226 ]. Although the number of fungal cyclic peptides is gradually increasing, it remains a group of natural products with relatively little skeletal diversity.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera Aspergillus, Penicillium, Fusarium, Acremonium and Amanita. Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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“…Three new cyclic peptides, Diffusa Cytide 1–3, were found in the leaves and roots of the white snake plant, and have particularly strong inhibitory effect on three kinds of prostate cancer cells; furthermore, they can inhibit the migration of prostate cancer cells in vitro at a concentration of 0.05 µM [ 43 ]. Currently, cyclic ACPs account for the majority of ACPs in clinical studies; these peptides have a strong inhibitory effect on cancer cells [ 44 ]. H-10, a novel cyclic pentapeptide, has a concentration-dependent inhibitory effect on mouse malignant melanoma B16 cells, with an IC 50 value of 39.68 µM with no toxicity to human peripheral lymphocytes and rat aortic smooth muscle cells [ 45 ].…”

Section: Classification Of Acpsmentioning

confidence: 99%

Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

2020

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Anti-cancer peptides (ACPs) are a series of short peptides composed of 10–60 amino acids that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour blood vessels, and are less likely to cause drug resistance. The aforementioned merits make ACPs the most promising anti-cancer candidate. However, ACPs may be degraded by proteases, or result in cytotoxicity in many cases. To overcome these drawbacks, a plethora of research has focused on reconstruction or modification of ACPs to improve their anti-cancer activity, while reducing their cytotoxicity. The modification of ACPs mainly includes main chain reconstruction and side chain modification. After summarizing the classification and mechanism of action of ACPs, this paper focuses on recent development and progress about their reconstruction and modification. The information collected here may provide some ideas for further research on ACPs, in particular their modification.

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“…These alkaloids can be widely synthesized by both terrestrial and marine organisms. A diversity of cyclopeptide alkaloids with intriguing structures and possible pharmaceutical activities has been identified from marine fungi, a well-known producer [55]. To the best of our knowledge, twelve cyclic peptides (97-105) were published from 2014 to 2018.…”

Section: Cyclopeptide Alkaloidsmentioning

confidence: 99%

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Yuan

et al. 2020

Marine Drugs

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Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

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Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications

Cited by 86 publications

References 76 publications

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

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