Structural characterization, thermal, DFT, cytotoxicity, and antimetastatic properties of cocaine complexes with La(III), Er(III), and Yb(III)

Zaki, Nadia G.; Mahmoud, Walaa H.; Kerdawy, Ahmed M. El; Abdallah, Abanoub Mosaad

doi:10.1007/s11164-020-04146-3

Cited by 18 publications

(7 citation statements)

References 61 publications

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Section: Resultsmentioning

confidence: 99%

“…In addition, H 2 L 2 ligand acted as mono negative bidentate chelating agent, coordinated to the metal ions via a nitrogen atom and deprotonated phenolic oxygen atom of the H 2 L 2 Schiff base ligand. [2,22,26] 3.4 | 1 H NMR spectra 1 H nuclear magnetic resonance (NMR) spectral data (δ ppm) of the free ligands were previously reported. [22,26] By comparing the spectral data of the free H ).…”

Section: Infrared Spectramentioning

confidence: 99%

“…The biological activity of the lanthanide complexes was credited to their special electronic configuration. [ 2 ] Lately, the research of coordination complexes of lanthanides has been intensively developing, which is related with the possibility of their practical application in the most modern technologies, biology, and medicine. [ 3 ] Lanthanide coordination compounds are the topic of extreme research efforts owing to their rare structures plus their potential applications in advanced materials, for example, Ln doped semiconductors, catalytic, fluorescent magnetic, and nonlinear optical materials.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, spectroscopic characterization, density functional, thermal studies, and molecular docking simulation of rare earth element complexes

Ahmed

Mohamed

2021

Applied Organom Chemis

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Section: Resultsmentioning

confidence: 99%

Section: Infrared Spectramentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis, spectroscopic characterization, density functional, thermal studies, and molecular docking simulation of rare earth element complexes

Ahmed

Mohamed

2021

Applied Organom Chemis

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“…[ 31–36 ] In 1909, cocaine (COC) (Figure 1a), a natural product containing azabicyclo[3.2.1]octane that is extracted from the leaves of the coca bush ( Erythroxylum coca ) plant, [ 37 ] was reported as an anticancer drug by Gilchrist. [ 38 ] Research in this regard has led to the recent development of different binary [ 39,40 ] and heteroleptic [ 41 ] metal complexes of COC exhibiting anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Abdallah

Zaki

Mahmoud

et al. 2021

Applied Organom Chemis

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In the field of transition metal chemistry, the development of transition metal‐based drugs for the treatment of diseases such as cancer or microbial infections with minimization of adverse effects and drug resistance constitutes an active area of research. Herein, eight novel nanosized heteroleptic complexes of cocaine/TMEDA with the formula [M(COC)(TMEDA)Cly(OH2)z]nCl·xH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II); COC = cocaine; TMEDA = N,N,N′,N′‐tetramethylethylenediamine, y = 1–2; z = 0–1; n = 0–1; and x = 0–2) were synthesized and structurally characterized via elemental analysis, molar conductivity, mass spectrometry, and spectroscopic and microscopic techniques. The thermal properties and kinetic thermodynamic parameters of the synthesized complexes were also studied. The geometry and electronic structures were investigated via density functional theory (DFT) calculations. The antiproliferative activity of the complexes on HepG‐2 and MCF‐7 cancer cell lines was quantified via MTT assay. The Fe(III) and Cd(II) complexes exhibited promising cytotoxic activities against the HepG‐2 and MCF‐7 cancer cell lines, respectively, with minimum effect on HFB4 human normal cells. Further molecular mechanistic studies were performed on the Cd(II) complex to inspect its influence on different cancer pathophysiology‐related processes in the MCF‐7 cell line including metastasis, apoptosis, and cellular oxidative stress and on the cellular levels of the human tumor suppressor nuclear proteins p21 and p27. The results revealed that the Cd(II) complex is a promising anticancer agent that acts through several molecular mechanisms with minimum effect on the normal cells and with additional antimetastatic properties. Furthermore, the antibacterial and antifungal activities of the prepared complexes were investigated.

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“…Cn was first reported as a cancer treatment by Gilchrist in 1909 [17]. Additionally, different binary transition metal complexes [18] and heteroleptic lanthanide-metal complexes [19] of Cn have been recently investigated for their anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

et al. 2019

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R EACTION of cocaine (Cn) with Mn(II) and Cu(II) chloride salts afforded complexes of the [M(Cn)Cl(OH 2) 3 ]Cl type which were structurally characterized by elemental analysis, conductance measurements, spectroscopic methods and mass spectrometry. Their thermal properties were studied. The in vitro antitumor activity of the newly synthesized complexes was investigated by MTT assay on MCF-7 and HepG-2 cell lines. Both complexes exhibited promising cytotoxic activity on both cell lines with high safety on normal human cells. Their antifungal activity against Aspergillus fumigatus and Candida albicans and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium and Escherichia coli were also included.

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Structural characterization, thermal, DFT, cytotoxicity, and antimetastatic properties of cocaine complexes with La(III), Er(III), and Yb(III)

Cited by 18 publications

References 61 publications

Synthesis, spectroscopic characterization, density functional, thermal studies, and molecular docking simulation of rare earth element complexes

Synthesis, spectroscopic characterization, density functional, thermal studies, and molecular docking simulation of rare earth element complexes

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

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