Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

Zaki, Nadia G.; Mahmoud, Walaa H.; Kerdawy, Ahmed M. El; Abdallah, Abanoub Mosaad; Mohamed, Gehad G.

doi:10.21608/ejchem.2019.16748.2019

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…oxidation, epoxidation, reduction, polymerization, ring-opening polymerization and Diels-Alder reactions. Their antibacterial, antifungal, antiviral and antitumor activities have been revealed [3][4][5][6]. Moreover, in recent research a number of Schiff bases have been used as highly selective fluorescent chemosensors and colorimetric sensors for cations.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in recent research a number of Schiff bases have been used as highly selective fluorescent chemosensors and colorimetric sensors for cations. Schiff base ligands and their complexes are used in pharmacology as antibacterial, anticancer, and antifungal agents [2,5,6]. Also, they are of significant interest for biochemistry, biomedicine, and environmental protection owing to their ability for chemical recognition of anions and metals.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization and Biological Activity Screening on Some Metal Complexes Based of Schiff Base Ligand

El‐Sonbati

Diab

Abbas³

et al. 2021

Egypt. J. Chem.

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A novel Schiff base ligand named (E)-2-(((3-hydroxyphenyl)imino)methyl)phenol (H2L) was prepared through condensation of 2-hydroxybenzaldehyde with 3-aminophenol in1:1 ratio. The ligand was characterized using spectroscopic techniques. La(III), Er(III) and Yb(III) complexes derived from H2L ligand have been prepared and characterized by conventional techniques including elemental analyses, infrared, electronic spectra, mass spectra, molar conductivity and thermal analysis. IR spectral data showed that H2L ligand is coordinated to the metal ions in a bi-negative tridentate manner through the azomethine nitrogen and two deprotonated phenolic oxygen atoms. The thermogravimetric analysis data of the complexes displays the existence of hydrated and coordinated water molecules in the complexes. The ligand and its complexes were evaluated for their antibacterial and antifungal activities against different gram positive bacteria (Staphylococcus Aureus and Bacillis subtilis), gram negative bacteria (Salmonella SP., Escherichia Coli and Pseudomonas aeruginosa) and fungi (Aspergillus Fumigates and Candida albicans). The complexes were found to have higher biological activity against bacteria and fungi more than the ligand. The calculated binding energy values of the receptors of the colon cancer (PDB code: 2hq6) and the lung cancer (PDB code: 1x2j) for Schiff base ligand (H2L) were discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Biological Activity Screening on Some Metal Complexes Based of Schiff Base Ligand

El‐Sonbati

Diab

Abbas³

et al. 2021

Egypt. J. Chem.

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“…The coordination of phenolic OH in coordination is further confirmed by the shift of ν(C-O) stretching vibration from 1235 cm -1 in the free ligand to 1220-1234 cm -1 in the IR spectra of the complexes [37]. Furthermore, the bands in the range of 428-486 cm -1 assigned to the stretching vibration mode of ν(M-N) [37][38][39], while the bands at 501-565 cm -1 indicates ν(M-O) stretching mode [38,40,41]. Likewise, the existence of coordinated water molecules in complexes was confirmed by two weak bands in the regions of 918-948 and 858-870 cm -1 due to ν(H2O) rocking and wagging modes of vibrations, respectively.…”

Section: Ft-ir Spectral Studymentioning

confidence: 99%

Studying of physicochemical properties of Coumarin based Nano-complexes for biomedical applications

2021

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Novel Schiff base ligand based on coumarin precursor was prepared by the condensation of 3-acetyl coumarin with 3-aminophenol. The newly synthesized Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) complexes were characterized by elemental analysis, molar conductivity, spectroscopic techniques (IR, 1 H NMR, mass spectrometry, UV-Vis), and thermal analysis (TG/DTG) to predict their structures. The resulting data displays octahedral complexes with 1M:1L ratio. The IR confirmed that the ligand coordinated to the metal ions in tridentate mode with ONO coordination sites. The complexes decomposed with three to five steps within the temperature range 30-900 C. Additionally, mass spectra of the ligand and its Cu(II) complex offer well matching data with calculated value. The molar conductivity values pointed out that the complexes were non-electrolytes. Molecular optimization of prepared compositions at DFT/ LANL2DZ level, besides Molecular docking between Schiff base ligand (HL) and the receptors of breast cancer were executed. Additionally, antibacterial activity has been evaluated against Streptococcus aureus and Escherichia coli. Additionally, fungicidal activity was screened in vitro against Aspergillus flavus and Candida albicans, using the disc diffusion method. The [Co(HL)Cl2.H2O].4H2O complex exhibits the highest antimicrobial effect against Streptococcus aureus with inhibition area 17mm, while against Escherichia coli it records 14mm, and 12mm against Candida albicans. The [Mn(L)Cl2.H2O].4H2O complex shows the lowest IC50 against human cancer (MCF-7 cells viability) with 22.2 µg/ml.

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“…[31][32][33][34][35][36] In 1909, cocaine (COC) (Figure 1a), a natural product containing azabicyclo[3.2.1]octane that is extracted from the leaves of the coca bush (Erythroxylum coca) plant, [37] was reported as an anticancer drug by Gilchrist. [38] Research in this regard has led to the recent development of different binary [39,40] and heteroleptic [41] metal complexes of COC exhibiting anticancer activity. This work describes the synthesis of new nanosized heteroleptic d-block complexes of COC using N,N,N 0 ,N 0tetramethylethane-1,2-diamine (TMEDA, Figure 1b) [42] as a coligand, which has been extensively utilized for metal complexation because of its high potential to improve the chelation rate of aromatic systems and the regiochemistry of these reactions [43][44][45][46][47] and the investigation of their cytotoxic activities against HepG-2 and MCF-7 cancer cell lines and their antibacterial and antifungal activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Abdallah

Zaki

Mahmoud

et al. 2021

Applied Organom Chemis

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In the field of transition metal chemistry, the development of transition metal‐based drugs for the treatment of diseases such as cancer or microbial infections with minimization of adverse effects and drug resistance constitutes an active area of research. Herein, eight novel nanosized heteroleptic complexes of cocaine/TMEDA with the formula [M(COC)(TMEDA)Cly(OH2)z]nCl·xH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II); COC = cocaine; TMEDA = N,N,N′,N′‐tetramethylethylenediamine, y = 1–2; z = 0–1; n = 0–1; and x = 0–2) were synthesized and structurally characterized via elemental analysis, molar conductivity, mass spectrometry, and spectroscopic and microscopic techniques. The thermal properties and kinetic thermodynamic parameters of the synthesized complexes were also studied. The geometry and electronic structures were investigated via density functional theory (DFT) calculations. The antiproliferative activity of the complexes on HepG‐2 and MCF‐7 cancer cell lines was quantified via MTT assay. The Fe(III) and Cd(II) complexes exhibited promising cytotoxic activities against the HepG‐2 and MCF‐7 cancer cell lines, respectively, with minimum effect on HFB4 human normal cells. Further molecular mechanistic studies were performed on the Cd(II) complex to inspect its influence on different cancer pathophysiology‐related processes in the MCF‐7 cell line including metastasis, apoptosis, and cellular oxidative stress and on the cellular levels of the human tumor suppressor nuclear proteins p21 and p27. The results revealed that the Cd(II) complex is a promising anticancer agent that acts through several molecular mechanisms with minimum effect on the normal cells and with additional antimetastatic properties. Furthermore, the antibacterial and antifungal activities of the prepared complexes were investigated.

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Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

Cited by 4 publications

References 19 publications

Preparation, Characterization and Biological Activity Screening on Some Metal Complexes Based of Schiff Base Ligand

Preparation, Characterization and Biological Activity Screening on Some Metal Complexes Based of Schiff Base Ligand

Studying of physicochemical properties of Coumarin based Nano-complexes for biomedical applications

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

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