Structural characterization of polysaccharides from<i>Cordyceps militaris</i>and their hypolipidemic effects in high fat diet fed mice

Huang, Zhenfeng; Zhang, Minglong; Song, Zhijun; Wang, Yahui; Jiang, Xue-wen

doi:10.1039/c8ra09068h

Cited by 19 publications

(10 citation statements)

References 51 publications

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“…The liver is an essential organ in the regulation of lipid metabolism, including the metabolism of TG and TC (Huang et al., 2018 ; Ting et al., 2018 ; X. Z. Wan et al., 2020 a; Zeng et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high‐cholesterol diet‐fed zebrafish

Kong

Liu

Dai

et al. 2021

Food Science & Nutrition

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Section: Discussionmentioning

confidence: 99%

Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high‐cholesterol diet‐fed zebrafish

Kong

Liu

Dai

et al. 2021

Food Science & Nutrition

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“…Many natural polysaccharides and polysaccharide-protein complexes isolated from fungi can be used as a source of therapeutic agents that are relatively non-toxic and show no significant side effects. In recent studies, polysaccharides of C. militaris have been identified to possess antitumor [10], immunomodulatory [11], anti-oxidant [12] and anti-hypolipidemic [13] effects. In this study, the SCR was fermented by C. militaris mycelium using solid fermentation.…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of crude polysaccharide extracted from fermented soybean curd residue by Cordyceps militaris

Ban

Meng

et al. 2021

Biotechnology & Biotechnological Equipment

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Cordyceps militaris is an edible and medicinal fungus that has been traditionally used as a crude drug for treatment of human disease. Meanwhile, the functional nutrient substances in C. militaris possess various physiological activities. In addition, re-utilizing the soybean curd residue as solid medium for producing edible and medicinal fungus is an efficient and commercial method to dispose of the soybean curd residue waste materials. In this study, soybean curd residue was utilized as solid medium raw material for fermentation by C. militaris mycelium. The crude polysaccharide (CSCPS) from fermented soybean curd residue and C. militaris mycelium mixture showed potent bioactivities, including antioxidant, antitumor and immunomodulatory activities. Based on five antioxidant assays, the CSCPS showed powerful antioxidant capacities at OH, DPPH and ABTS radical scavenging assays. The CSCPS significantly activated the proliferation of RAW 264.7, and protected it from DOX-induced and LPS-stimulated cell damage. Furthermore, the CSCPS inhibited the proliferation of HT1080, Hela, A549, U-2 OS and MDA-MB-231 cells.

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“…An in vitro experiment and an in vivo study in rodents also confirmed the hypolipidemic activity of the polysaccharide fractions isolated from C. militaris [146,147]. Similarly, Huang et al [148] demonstrated the hypolipidemic activity of intracellular (IPCM) and extracellular polysaccharides (EPCM) from C. militaris in mice fed a high-fat diet.…”

Section: Effect Of C Militaris On the Cardiovascular Systemmentioning

confidence: 66%

Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity

Jędrejko

Lazur

Muszyńska

2021

Foods

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Cordyceps spp. mushrooms have a long tradition of use as a natural raw material in Asian ethnomedicine because of their adaptogenic, tonic effects and their ability to reduce fatigue and stimulate the immune system in humans. This review aims to present the chemical composition and medicinal properties of Cordyceps militaris fruiting bodies and mycelium, as well as mycelium from in vitro cultures. The analytical results of the composition of C. militaris grown in culture media show the bioactive components such as cordycepin, polysaccharides, γ-aminobutyric acid (GABA), ergothioneine and others described in the review. To summarize, based on the presence of several bioactive compounds that contribute to biological activity, C. militaris mushrooms definitely deserve to be considered as functional foods and also have great potential for medicinal use. Recent scientific reports indicate the potential of cordycepin in antiviral activity, particularly against COVID-19.

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Structural characterization of polysaccharides fromCordyceps militarisand their hypolipidemic effects in high fat diet fed mice

Abstract: Structural characterization and comparative evaluation of hypolipidemic activities of intracellular and extracellular polysaccharides from Cordyceps militaris.

Cited by 19 publications

References 51 publications

Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high‐cholesterol diet‐fed zebrafish

Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high‐cholesterol diet‐fed zebrafish

Bioactivities of crude polysaccharide extracted from fermented soybean curd residue by Cordyceps militaris

Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity

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