Structural characterization and antidiabetic activity of a glucopyranose-rich heteropolysaccharide from Catathelasma ventricosum

Liu, Yuntao; Chen, Di; You, Yuxian; Zeng, Siqi; Hu, Yu; Duan, Xiaoyu; Liu, Aiping; Chen, Hong; Hu, Xinjie; Chen, Shujuan; Li, Cheng; Chen, Shuai

doi:10.1016/j.carbpol.2016.04.106

Cited by 42 publications

(15 citation statements)

References 29 publications

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“…The different molecular weight of polysaccharides acquired from Ophiopogon japonicas (MW: 3.47, 6.746, 35.2, 124.3, and 324.6 kDa), Acaudina molpadioides (MW: 1614.1 kDa), and mulberry leaf (MW: 289) reduced hyperglycemia and hyperinsulinemia in STZ-induced diabetic mice. Polysaccharide triggers the PI3K/Akt signaling pathway through IRS1, PI3K-p85, and phosphorylated Akt develops insulin sensitivity [26,123,143] and improves diabetic-associated renal disease [144]. Moreover, treatment of these polysaccharides increased GLUT4 levels in pancreas and decreased glycogen synthase kinase-3 β levels in most of the cells.…”

Section: Mechanism Of Dietary Polysaccharides On Anti-diabetic Actmentioning

confidence: 99%

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Ganesan

2019

Molecules

117

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Diabetes mellitus is a multifactorial, heterogeneous metabolic disorder, causing various health complications and economic issues, which apparently impacts the human’s life. Currently, commercial diabetic drugs are clinically managed for diabetic treatment that has definite side effects. Dietary polysaccharides mainly derive from natural sources, including medicinal plants, grains, fruits, vegetables, edible mushroom, and medicinal foods, and possess anti-diabetic potential. Hence, this review summarizes the effects of dietary polysaccharides on diabetes and underlying molecular mechanisms related to inflammatory factors, oxidative stress, and diabetes in various animal models. The analysis of literature and appropriate data on anti-diabetic polysaccharide from electronic databases was conducted. In vivo and in vitro trials have revealed that treatment of these polysaccharides has hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects, which enhance pancreatic β-cell mass and alleviates β-cell dysfunction. It enhances insulin signaling pathways through insulin receptors and activates the PI3K/Akt pathway, and eventually modulates ERK/JNK/MAPK pathway. In conclusion, dietary polysaccharides can effectively ameliorate hyperglycemia, hyperlipidemia, low-grade inflammation, and oxidative stress in type 2 diabetes mellitus (T2DM), and, thus, consumption of polysaccharides can be a valuable choice for diabetic control.

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Section: Mechanism Of Dietary Polysaccharides On Anti-diabetic Actmentioning

confidence: 99%

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Ganesan

2019

Molecules

117

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“…In an investigation of the relationship between structure and the reported antihyperglycemic effect of polysaccharides from Catathelasma ventricosum mushrooms, Liu et al [ 18 , 33 , 34 ], describe their isolation and characterization. The freeze-dried powdered mushrooms (200 g) were defatted and decolorized with 95% ethanol and the suspension was centrifuged.…”

Section: Isolation and Characterization Of Mushroom Polysaccharidementioning

confidence: 99%

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Friedman

2016

Foods

267

150

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More than 2000 species of edible and/or medicinal mushrooms have been identified to date, many of which are widely consumed, stimulating much research on their health-promoting properties. These properties are associated with bioactive compounds produced by the mushrooms, including polysaccharides. Although β-glucans (homopolysaccharides) are believed to be the major bioactive polysaccharides of mushrooms, other types of mushroom polysaccharides (heteropolysaccharides) also possess biological properties. Here we survey the chemistry of such health-promoting polysaccharides and their reported antiobesity and antidiabetic properties as well as selected anticarcinogenic, antimicrobial, and antiviral effects that demonstrate their multiple health-promoting potential. The associated antioxidative, anti-inflammatory, and immunomodulating activities in fat cells, rodents, and humans are also discussed. The mechanisms of action involve the gut microbiota, meaning the polysaccharides act as prebiotics in the digestive system. Also covered here are the nutritional, functional food, clinical, and epidemiological studies designed to assess the health-promoting properties of polysaccharides, individually and as blended mixtures, against obesity, diabetes, cancer, and infectious diseases, and suggestions for further research. The collated information and suggested research needs might guide further studies needed for a better understanding of the health-promoting properties of mushroom polysaccharides and enhance their use to help prevent and treat human chronic diseases.

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“…A heteropolysaccharide with a molecular weight of 15 kDa was found to have hypoglycemic, and hypolipidemic activities on the streptozotocin-induced diabetic mouse, and the FBG level was reduced by 48.58% aer polysaccharides treatment (100 mg per kg per day), in comparison with the diabetic control. 31 Polysaccharide fraction from Opuntia dillenii Haw. fruits (200 mg per kg per day) could signicantly decrease FBG level by 34.4% using streptozotocininduced diabetic mouse model, compared with diabetic control rats.…”

Section: Effect Of Glp On the Fasting Blood Glucose Levels And Oral Gmentioning

confidence: 99%

Advantages of the polysaccharides from Gracilaria lemaneiformis over metformin in antidiabetic effects on streptozotocin-induced diabetic mice

et al. 2017

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Structural characterization and antidiabetic activity of a glucopyranose-rich heteropolysaccharide from Catathelasma ventricosum

Cited by 42 publications

References 29 publications

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Advantages of the polysaccharides from Gracilaria lemaneiformis over metformin in antidiabetic effects on streptozotocin-induced diabetic mice

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