2009
DOI: 10.1152/ajprenal.00110.2008
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Structural and functional changes in the kidneys of high-fat diet-induced obese mice

Abstract: Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is reported to induce systemic metabolic abnormalities and subsequent renal injuries, such as albuminuria, similar to human metabolic syndrome, alterations in HFD-induced renal injuries have not been fully elucidated in detail. We therefore investigated the structural and functional changes in the kidneys of C57BL/6 mice on a HFD. Six-we… Show more

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Cited by 231 publications
(227 citation statements)
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“…Clinical factors, including hypertension, diabetes mellitus, obesity, abnormal lipid levels and vitamin deficiency, as well as tissue factors such as increased activity of the renin-angiotensin-aldosterone system, increased levels of advanced glycation end products, oxidative stress, decreased nitric oxide, TGF-β, have been associated with increasing renal aging (Choudhury & Levi 2011). In addition, HFD-induced obese mice showed pathophysiological changes including albuminuria, increase in glomerular tuft area, mesangial expansion, renal lipid accumulation, increased collagen in glomeruli, increased macrophage infiltration in medulla, and impaired sodium handling (Deji et al 2009). Therefore, we could suppose that aging combined with HFD feeding are considered to further increase the risk of development or progression of renal injury.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Clinical factors, including hypertension, diabetes mellitus, obesity, abnormal lipid levels and vitamin deficiency, as well as tissue factors such as increased activity of the renin-angiotensin-aldosterone system, increased levels of advanced glycation end products, oxidative stress, decreased nitric oxide, TGF-β, have been associated with increasing renal aging (Choudhury & Levi 2011). In addition, HFD-induced obese mice showed pathophysiological changes including albuminuria, increase in glomerular tuft area, mesangial expansion, renal lipid accumulation, increased collagen in glomeruli, increased macrophage infiltration in medulla, and impaired sodium handling (Deji et al 2009). Therefore, we could suppose that aging combined with HFD feeding are considered to further increase the risk of development or progression of renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, HFD feeding in mice has been known to induce characteristics of metabolic syndrome including obesity, hyperglycemia, hyperinsulinemia, dyslipidemia, and hypertension. These systemic changes combined with local alterations in the kidney with aging are considered to further increase the risk of development or progression of chronic kidney disease (Deji et al 2009). However, the effect of aging on HFD-induced renal injury has not been determined.…”
Section: Introductionmentioning
confidence: 99%
“…31 The primary histologic features are relatively few lesions of focalsegmental glomerulosclerosis, profound glomerulomegaly because of glomerular hyalinosis and fibrosis, as well as lipid accumulation in the glomeruli and adhesion to Bowman's capsule. 32,33 Some studies suggest that lipid accumulation is a result of alterations in fat metabolism.…”
Section: Structural Changes In the Kidneymentioning
confidence: 99%
“…Metformin Reduces Renal Inflammation, Apoptosis, and Fibrosis-Clinical and experimental studies highlighted the association of high fat diet with inflammation and apoptosis (24,25). Hence, we also checked the molecular markers of renal inflammation, apoptosis, and fibrosis.…”
Section: High Fat Diet Feeding Induces Insulinmentioning
confidence: 99%