Structural and antibacterial activity of hydroxyapatite and fluorohydroxyapatite co-substituted with zirconium–cerium ions

Sanyal, Vijayalakshmi; Raja, C. Ramachandra

doi:10.1007/s00339-016-9621-x

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…since archaic time. , The antibacterial response of HA–Ag biocomposites depends on Ag content in the composite against both Gram-positive and Gram-negative bacteria. , Ag concentrations of 10, 50, and 100 μg/cm in HA have demonstrated to inhibit the growth of E. coli bacteria by 62%, 88%, and 100%, respectively, after 24 h of incubation Table summarizes the antibacterial response of various HA-based biocomposites against both Gram-positive and Gram-negative bacteria. ,− , …”

Section: Antimicrobial Response Of Tailored Biocompositesmentioning

confidence: 99%

“…34 Table 1 summarizes the antibacterial response of various HA-based biocomposites against both Gram-positive and Gram-negative bacteria. 26,[34][35][36][37][38][39][40][41][42]62 There are two main mechanisms responsible for the antibacterial activity of Ag. One of them is the formation of Ag + ions by its oxidation, which is considered to be highly reactive with bacteria.…”

Section: Antimicrobial Response Of Tailored Biocompositesmentioning

confidence: 99%

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Various Biomaterials and Techniques for Improving Antibacterial Response

Singh

Dubey

2018

ACS Appl. Bio Mater.

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The majority of failures in prosthetic implants and devices are caused by infections. Microbial infections are one of the major causes of these failures. The present article reviews various techniques such as modification in surface chemistry/composition and tailored structures (micro to nano) for improving the antibacterial response of prosthetic implants. In addition, the application of external stimulants such as magnetic and electric fields, as well as polarization, is recently realized as a fairly appealing approach to diminish the bacterial population. A comprehensive response of surface modifications as well as external stimuli in inducing the antibacterial response in prosthetic implants has also been summarized. The mechanisms for the antibacterial response due to these modifications, such as generation of toxic metal ions by dissolution of their respective oxides, and production of reactive oxygen species (ROS), such as singlet oxygen, hydroxyl radicals (OH–), hydrogen peroxide (H2O2), superoxides, peroxides (O2 –2), etc., have been elaborately discussed.

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Section: Antimicrobial Response Of Tailored Biocompositesmentioning

confidence: 99%

Section: Antimicrobial Response Of Tailored Biocompositesmentioning

confidence: 99%

Various Biomaterials and Techniques for Improving Antibacterial Response

Singh

Dubey

2018

ACS Appl. Bio Mater.

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“…In this respect, we acknowledge the recent contributions focused to ascertain both synergic ion doping combinations and their optimal concentration. So far, HA has been co-substituted with: Ag/Bi [523], Ag/F [524], Ag/Mg [525,526], Ag/Si [527], Ag/Sr [528,529], Ag/Zn [281,530], Ce/Fe [381], Ce/Eu [531], Sr/Ce [344,532], Sr/Cu [533], Sr/Zn [534,535], Zn/Cu [533,536], Zn/F [78], Zn/Fe [537], La/Ag [405], La/Cu [538], Sm/Gd [354], Tb/Gd [539], Ce/Zr/F [540], Ag/Ti/F [541], Mg/Zn/Co [542], Sr/Co/F [543], Ag/Cu/Zn/F [544], or Ag/Cu/Zn/Ti [545].…”

Section: Future Perspectives: Co-substituted Hydroxyapatite Biocermentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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“…Sanyal and Raja [42] studied the effect of the co-substitution of zirconium (Zr) and cerium (Ce) on the structure of hydroxyapatite (HAp) and fluorohydroxyapatite (FHA) gel. The samples were confirmed by the FTIR and XRD spectra; in addition, it was observed that with the increase of the concentration of the Zr 4+ and Ce 3+ ions, the formation of the HA phase was maintained.…”

Section: Biomaterials -Physics and Chemistry -New Editionmentioning

confidence: 99%

Tuned Hydroxyapatite Materials for Biomedical Applications

Vieira¹,

Vieira²,

Silva³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

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Hydroxyapatite stands out between biomaterials due to its properties of osteoconduction and osteoinduction, being adequate to be used in bone grafts. The high stability and flexibility of the structure allows for several biomedical applications, for example, the use as polysaccharide based on the scaffold formulations and the cationic substitutions occurring through the doping of the material using metals, which may enhance biological characteristics, such as improving the action of combating bacterial infections in situ. This study was a research of articles and patents, without and with time restriction (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017), which contain information about hydroxyapatite in the tissue engineering, biomedical, doped with cerium and its properties of antibacterial activity.There were also searches of products and companies that commercialize these types of materials aimed at tissue engineering area. Scopus was used for searched of articles and were EPO, USPTO, and INPI used for patents, and to search for products and companies were used search engines. Few papers were found to associate all the keywords, but the ones found are recent works, thus showing a new area with potential to be investigated.

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Structural and antibacterial activity of hydroxyapatite and fluorohydroxyapatite co-substituted with zirconium–cerium ions

Cited by 10 publications

References 43 publications

Various Biomaterials and Techniques for Improving Antibacterial Response

Various Biomaterials and Techniques for Improving Antibacterial Response

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Tuned Hydroxyapatite Materials for Biomedical Applications

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