Various Biomaterials and Techniques for Improving Antibacterial Response

Singh, Angaraj; Dubey, Ashutosh Kumar

doi:10.1021/acsabm.8b00033

Cited by 98 publications

(69 citation statements)

References 200 publications

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“…The use of nanotechnology is a viable prospective that can be employed in order to address this issue effectively [7]. Nanomaterials based on metal ions, have an outstanding of cytotoxicity activity against bacteria, fungi and viruses.…”

Section: Introductionmentioning

confidence: 99%

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Muñoz-Escobar

Reyes-López

2020

PLoS ONE

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The integration of metallic or ceramic nanoparticles in polymer matrices has improved the antimicrobial and antifungal behavior, resulting in the search for composites with increased bactericidal and antimycotic properties. A polycaprolactone fibers with copper oxide nanoparticles was prepared. Polycaprolactone-copper fibers (PCL-CuONPs) were prepared into two major steps in situ method: (a) Synthesis of CuO particles, then (b) incorporation of polycaprolactone to electrospun process. The first step is the reduction of Cu+2 ions by gallic acid in N,N-dimethylformamide and tetrahydrofuran solution with the simple addition of polycaprolactone in the solution for the second electrospun step. Raman spectra provide information about the nature of the copper oxide synthesized. There are three Raman peaks in the sample, at 294 and 581 cm-1 and a very broad band from 400 to 600 cm-1 which are characteristics bands for CuO. Scanning electron microscopy (TEM) revealed copper oxide nanoparticles with semispherical shapes with diameter 35 ±11 nm. Dynamic light scattering (DLS) analysis showed uniform CuONPs in a range of 88±11 nm. Scanning electron microscopy (SEM) of PCL-CuONps reveled fibers with diameters ranging from 925 to 1080 nm were successfully obtained by electrospinning technique. Orientation, morphology and diameter were influenced by the increment on CuONPs concentration, with the smaller diameter present in samples prepared from low concentrated solutions. The antimycotic applicability of the composite was evaluated to determine the antifungal activity in three species of the genus Candida (Candida albicans, Candida glabrata and Candida tropicalis). PCL-CuONPs exhibit a considerable antifungal effect on all species tested. The preparation of PCL-CuONPs was simple, fast and low-cost for practical application as an antifungal dressing.

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Section: Introductionmentioning

confidence: 99%

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Muñoz-Escobar

Reyes-López

2020

PLoS ONE

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“…The surface modification using HA-ZnO nanocomposite can reduce ions leaching from a metal alloy and prevents the bacteria colonization over a bioimplant surface (Figure 4c) [118]. The experimental investigation suggested that the number of bacterial colonies could be reduced to 13% from 50.45% when ZnO content was increased from 1.5% to 30% (wt) in a HA-ZnO nanocomposite.…”

Section: Surface Coating Using Zno-based Nanocompositementioning

confidence: 97%

“…Nanomaterials are the advanced materials that could be effectively utilized to improve the surface and bulk properties of orthopedic bioimplants. A class of nanomaterials in response to electric/magnetic fields or polarization exhibit anti-bacterial properties without affecting the surface chemistry of bioimplants [118]. Nanotechnologies could improve the antibacterial response of the prosthetic bioimplants, which include compositional modification, surface chemistry alteration, as well as the application of properly tuned external stimuli [7,118].…”

Section: Surface Modification Effectsmentioning

confidence: 99%

“…A class of nanomaterials in response to electric/magnetic fields or polarization exhibit anti-bacterial properties without affecting the surface chemistry of bioimplants [118]. Nanotechnologies could improve the antibacterial response of the prosthetic bioimplants, which include compositional modification, surface chemistry alteration, as well as the application of properly tuned external stimuli [7,118]. Various desirable surface properties such as protein adsorption, osteoblast attachment, osteoblast differentiation, antibacterial activity, biocompatibility with living tissues is achieved through nanomaterials.…”

Section: Surface Modification Effectsmentioning

confidence: 99%

“…[120]. Adapted with permission from [118]; 2018 ACS Publications; Adapted with permission from [120]; 2019 Elsevier; Adapted with permission from [123]; 2011 SAGE Publications.…”

Section: Surface Coating Using Nano-tio 2 and Tio 2 -Based Metal Nanomentioning

confidence: 99%

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Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

et al. 2020

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Significant research and development in the field of biomedical implants has evoked the scope to treat a broad range of orthopedic ailments that include fracture fixation, total bone replacement, joint arthrodesis, dental screws, and others. Importantly, the success of a bioimplant depends not only upon its bulk properties, but also on its surface properties that influence its interaction with the host tissue. Various approaches of surface modification such as coating of nanomaterial have been employed to enhance antibacterial activities of a bioimplant. The modified surface facilitates directed modulation of the host cellular behavior and grafting of cell-binding peptides, extracellular matrix (ECM) proteins, and growth factors to further improve host acceptance of a bioimplant. These strategies showed promising results in orthopedics, e.g., improved bone repair and regeneration. However, the choice of materials, especially considering their degradation behavior and surface properties, plays a key role in long-term reliability and performance of bioimplants. Metallic biomaterials have evolved largely in terms of their bulk and surface properties including nano-structuring with nanomaterials to meet the requirements of new generation orthopedic bioimplants. In this review, we have discussed metals and metal alloys commonly used for manufacturing different orthopedic bioimplants and the biotic as well as abiotic factors affecting the failure and degradation of those bioimplants. The review also highlights the currently available nanomaterial-based surface modification technologies to augment the function and performance of these metallic bioimplants in a clinical setting.

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Electron Spin Polarization Engineering in Ferromagnetic Bioheterojunction for Sonotherapy of Osteomyelitis

Ding,

Li,

Liu

et al. 2024

Adv Funct Materials

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Electron spinning polarization has garnered increased attention for its potential to enhance device properties. However, its application in life health, specifically in anti‐infection and tissue repair, remains under‐explored. In this study, a ferromagnetic heterojunction CF (Fe3O4/TiO2) is constructed with spin‐polarized electrons, demonstrating efficient antibiosis performance with ultrasound (US) assistance. The antibacterial mechanism is elucidated as follows: spin‐polarized metallic states of Fe3O4 induce an asymmetric distribution in the electron spin state of TiO2, increasing the density of states of spin‐polarized electrons near the Fermi level of CF. Under US treatment, the built‐in electric field and spin‐polarized electrons in CF synergistically suppress the recombination of sono‐activated carriers, promoting reactive oxygen species (ROS) production. Simultaneously, the bacterial membrane is influenced by the micromagnetic field induced by spin‐polarized electrons, causing a severe disturbance in the bacterial respiratory chain. The combined damage from ROS and disturbed respiratory chain results in bacterial death. Fortunately, the micromagnetic field built by CF activates specific mechanosensitive ion channels, including TREK1, Piezo1, and related pathways, enhancing osteoblast differentiation. Sonotherapy using CF exhibits an excellent therapeutic effect in treating osteomyelitis. This study provides novel insights into manipulating spin electrons for applications in life health.

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Various Biomaterials and Techniques for Improving Antibacterial Response

Cited by 98 publications

References 200 publications

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

Electron Spin Polarization Engineering in Ferromagnetic Bioheterojunction for Sonotherapy of Osteomyelitis

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