Strontium-Containing Barium Titanate-Modified Titanium for Enhancement of Osteointegration

Abstract

One of the major challenges for Ti-based implants is insufficient osteointegration, which might result in the loosening of the implant. In this study, we fabricated strontium (Sr)-containing barium titanate (BST) on the surface of Ti to improve the bioactivity for osteointegration enhancement. The introduction of Sr significantly reduced the crystallization time and improved crystallinity, which was proved by X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. Compared with Ti, the BST film showed greater wettability surface and lower elastic modulus and hardness. Furthermore, in synergy with the release of Sr ions, the BST film improved early adhesion and followed osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, the bone implantation experiment suggested that the BST film could significantly improve the in vivo osteogenesis and osteointegration capabilities of Ti implants. In summary, this study revealed that BST-modified Ti has potential application in bone repair.

A cytocompatible microporous Sr-doped titanium dioxide coating fabricated by plasma electrolytic oxidation

“…The MT-Sr coating prepared by micro-arc oxidation in this study exhibited a porous surface structure, and more importantly, strontium was introduced into the coating during the micro-arc oxidation process. Research showed that strontium induced MC3T3-E1 cells to differentiate into osteoblasts, which enables proliferation of the osteoblasts, and inhibits the proliferation of osteoclasts and bone absorption, so strontium plays an important role in the process of bone formation (Zhou et al, 2022). The results of this study showed that on the first day after cell inoculation on the material surface, the amounts of cells adhered to the surfaces of each group of samples were different.…”

Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds

“…3a, the diffraction peaks at 22.2°, 31.4°, 38.9°, 45.3°, 51.0°, 56.2°, 66.1°, 70.4° and 75.1° were in agreement with the (100), (110), (111), (002)/(200), (210), (211), (220), (212) and (310) crystal planes of BTO. 29 Among them, a split peak could be observed at around 45°, which is the characteristic peak of tetragonal piezoelectric BTO. 30 All the above peaks match well with the PDF card (JCPDS data No.…”

“…3a, the 210), ( 211), ( 220), ( 212) and (310) crystal planes of BTO. 29 Among them, a split peak could be observed at around 45°, which is the characteristic peak of tetragonal piezoelectric BTO. 30 All the above peaks match well with the PDF card (JCPDS data No.…”

Developing alkaline titanate surfaces for medical applications

“…Zhou et al . [239] described the formation of barium titanate films, which were subsequently doped with strontium (Sr) ions, for improved bioactivity for osseointegration enhancement; Sr has been shown to activate various signalling pathways in osteoblasts and osteoclasts, such as the calcium-sensing receptor, inositol 1,4,5 triphosphate, MAPK-ERK1/2 and Wnt/NFATc, enabling bone stem cell osteogenic differentiation and inhibiting osteoclast activity. Due to Sr and Ba having similar ionic radii (1.12 and 1.34 Å, respectively [240]) and electronic structures, substituting Sr into the barium titanate structure is a logical step to not only modify the piezoelectric properties of barium titanate, but to also improve the bioactivity.…”