Strong and biocompatible poly(lactic acid) membrane enhanced by Ti3C2Tz (MXene) nanosheets for Guided bone regeneration

Chen, Ke; Chen, Youhu; Deng, Qihuang; Jeong, Sunjoo; Jang, Tae‐Sik; Du, Shiyu; Kim, Hyoun‐Ee; Huang, Qing; Han, Cheol-Min

doi:10.1016/j.matlet.2018.06.063

Cited by 120 publications

(56 citation statements)

References 14 publications

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“…31 Chen et al prepared a OTES-Ti 3 C 2 T z /PLA composite membrane and found that the addition of 1 wt.% Ti 3 C 2 T z nanosheets enhances cell proliferation and osteogenic differentiation ability of PLA. 32 Owing to the good physiochemical performance, unique structure and biological compatibility of 2D materials, we hypothesize that MXenes are suitable for bone tissue engineering application and GBR treatment similar to graphene.…”

Section: Introductionmentioning

confidence: 99%

<p>Multilayered Titanium Carbide MXene Film for Guided Bone Regeneration</p>

Zhang¹,

Fu²,

Mo³

2019

IJN

101

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Purpose: MXenes are two-dimensional (2D) materials that are increasingly being applied in biomedical fields. This is ascribed to their good physiochemical properties, unique structure and high biological compatibility. However, the osteogenic activity and suitability of these materials for bone tissue engineering are not clearly understood. Thus, the aim of this study is to evaluate the biocompatibility, osteoinductivity and guided bone regeneration ability of Ti 3 C 2 T x MXene in vitro and in vivo. Methods: Multilayered Ti 3 C 2 T x MXene films were prepared and characterized by XRD and SEM. In vitro experiments were performed to evaluate the effect of MXene films on cell adhesion and morphology with SEM and fluorescence microscopy. The cytotoxicity of MXene films was detected with the Live/Dead double-staining tests. The EdU assay was employed to evaluate cell proliferation on MXene films and ALP activity was tested to determine the effect of the films on osteogenic differentiation in vitro. The mRNA expression of osteogenic differentiation-related markers was measured using qRT-PCR. In vivo animal studies were performed in which the MXene films were implanted subcutaneously in rats to evaluate biocompatibility and host tissue response in vivo. In addition, a rat calvarial defect model was established to examine the bone regeneration performance of the Ti 3 C 2 T x MXene films. The specimens were analyzed with micro-CT evaluation and histological tests. Results: The XRD and SEM analyses revealed that the Ti 3 C 2 T x MXene film was successfully synthesized. The cellular experiments showed that MXene films were highly cytocompatible and enhanced osteogenic differentiation in vitro. When implanted into subcutaneous sites and calvarial defect sites in rats, MXene films showed good biocompatibility, osteoinductivity and bone regeneration activity in vivo. Conclusion: In summary, this study presents new applications of MXenes in bone tissue engineering and in guided bone regeneration therapy.

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Section: Introductionmentioning

confidence: 99%

<p>Multilayered Titanium Carbide MXene Film for Guided Bone Regeneration</p>

Zhang¹,

Fu²,

Mo³

2019

IJN

101

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“…Several studies on toxicity and osteogenic differentiation induction for pre-osteoblast have been published before 2020, as MXene is expected to favor bone-tissue engineering due to its hydrophilicity and mechanical properties [ 16 , 20 ]. However, there are, yet, no reports of the effects of MXene particles on biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs).…”

Section: Resultsmentioning

confidence: 99%

“…Despite the interest as a biomaterial, little is known about the interactions of MXenes with stem cells or their biological tissue affinity [ 10 ]. MXenes have been applied as bone regeneration composites due to their excellent mechanical properties for tissue engineering [ 15 , 16 ]. However, there are no reports on the osteo-inductive or -conductive properties of MXene particles or flakes.…”

Section: Introductionmentioning

confidence: 99%

Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

Jang

Lee

2021

Materials

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MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti3C2 MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression.

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“…For instance, a biocompatible OTES‐Ti3C2Tz/PLA nanocomposite was developed for the in vitro MC3T3‐E1 mouse preosteoblasts proliferation, adhesion, and osteogenic differentiation. They reported a higher ultimate tensile strength of the nanocomposite membranes as compared to the PLA membrane alone (33%) 251 . Moreover, it was reported that TiO 2 on the three‐dimensional (3D) printed PLGA/TiO 2 construct could improve the ALP activity as well as HA formation of the osteoblast cells cultured on the nanocomposite for bone tissue regeneration.…”

Section: Targeted Drug Delivery Systemsmentioning

confidence: 99%

Targeted nanomedicines for the treatment of bone disease and regeneration

Ordikhani

Zandi

Mazaheri

et al. 2020

Medicinal Research Reviews

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Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone‐targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical applications. In the present review, the latest advancements in targeting moieties and nanocarrier drug delivery systems for the treatment of bone diseases are summarized. We also review the regeneration capability and effective delivery of nanomedicines for orthopedic applications.

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Strong and biocompatible poly(lactic acid) membrane enhanced by Ti3C2Tz (MXene) nanosheets for Guided bone regeneration

Cited by 120 publications

References 14 publications

<p>Multilayered Titanium Carbide MXene Film for Guided Bone Regeneration</p>

<p>Multilayered Titanium Carbide MXene Film for Guided Bone Regeneration</p>

Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

Targeted nanomedicines for the treatment of bone disease and regeneration

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