Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

Jang, JunHwee; Lee, Eunjung

doi:10.3390/ma14164453

Cited by 24 publications

(27 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treating human mesenchymal stem cells (hMSCs) with a high dose of Ti 3 C 2 T x nanosheets (>50 μg mL −1 ) led to obvious cytotoxicity, as shown in [ 37 ]. At a dose of 100 μg mL −1 , hMSCs displayed a significant decrease of cell proliferation early in this study.…”

Section: In Vitro Toxic Effects Of Mxenesmentioning

confidence: 99%

Safety Assessment of 2D MXenes: In Vitro and In Vivo

2022

Nanomaterials

View full text Add to dashboard Cite

MXenes, representing a new class of two-dimensional nanomaterial, have attracted intense interest in a variety of fields as supercapacitors, catalysts, and sensors, and in biomedicine. The assessment of the safety of MXenes and related materials in biological systems is thus an issue that requires significant attention. In this review, the toxic effects of MXenes and their derivatives are summarized through the discussion of current research into their behaviors in mammalian cells, animals and plants. Numerous studies have shown that MXenes have generally low cytotoxicity and good biocompatibility. However, a few studies have indicated that MXenes are toxic to stem cells and embryos. These in vitro and in vivo toxic effects are strongly associated with the dose of material, the cell type, the mode of exposure, and the specific type of MXene. In addition, surface modifications alter the toxic effects of MXenes. The stability of MXenes must be considered during toxicity evaluation, as degradation can lead to potentially toxic byproducts. Although research concerning the toxicity of MXenes is limited, this review provides an overview of the current understanding of interactions of MXenes with biological systems and suggests future research directions.

show abstract

Section: In Vitro Toxic Effects Of Mxenesmentioning

confidence: 99%

Safety Assessment of 2D MXenes: In Vitro and In Vivo

2022

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Moreover, the mass ratio of MXene NPs in the nanofibrous matrices was carefully selected and used for the electrospinning process, taking into account the volume of the polymer solution and the results of the nanofibrous sheet (i.e., disc shape with 9 mm diameter). Based on the previous reports [ 13 , 35 ], we assumed that the mass ratio of the MXene NPs in the defined area was within the range of the optimized mass ratio evaluated by a series of the experiments, such as cytotoxicity and ALP activity tests. With a similar but slightly different from the previous approach, we also postulated that the MXene NPs in the nanofiber matrices may act differently on the cell behaviors because they are embedded in the surface of the matrices rather than placed on the cell culture plates.…”

Section: Resultsmentioning

confidence: 99%

Ternary MXene-loaded PLCL/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation

Lee

Jeon

et al. 2022

Nano Convergence

View full text Add to dashboard Cite

Conventional bioinert bone grafts often have led to failure in osseointegration due to low bioactivity, thus much effort has been made up to date to find alternatives. Recently, MXene nanoparticles (NPs) have shown prominent results as a rising material by possessing an osteogenic potential to facilitate the bioactivity of bone grafts or scaffolds, which can be attributed to the unique repeating atomic structure of two carbon layers existing between three titanium layers. In this study, we produced MXene NPs-integrated the ternary nanofibrous matrices of poly(L-lactide-co-ε-caprolactone, PLCL) and collagen (Col) decorated with MXene NPs (i.e., PLCL/Col/MXene), as novel scaffolds for bone tissue engineering, via electrospinning to explore the potential benefits for the spontaneous osteogenic differentiation of MC3T3-E1 preosteoblasts. The cultured cells on the physicochemical properties of the nanofibrous PLCL/Col/MXene-based materials revealed favorable interactions with the supportive matrices, highly suitable for the growth and survival of preosteoblasts. Furthermore, the combinatorial ternary material system of the PLCL/Col/MXene nanofibers obviously promoted spontaneous osteodifferentiation with positive cellular responses by providing effective microenvironments for osteogenesis. Therefore, our results suggest that the unprecedented biofunctional advantages of the MXene-integrated PLCL/Col nanofibrous matrices can be expanded to a wide range of strategies for the development of effective scaffolds in bone tissue regeneration. Graphical Abstract

show abstract

“…Researchers assessed the osteogenic activity of MXene on human Mesenchymal Stem Cells (hMSCs) with cell culture medium containing different concentrations of MXene. 92 When the concentration was <20 μg/ml, hMSCs showed distinct proliferation and osteogenic differentiation activity. Moreover, the rising expression of early osteogenic genes RUNX2 and OPN and late osteogenic gene BSP was also observed under the stimulation of MXene.…”

Section: Mxene Nanomaterials For Bone Tissue Engineering and Regenera...mentioning

confidence: 98%

“…To date, many scholars have made numerous efforts in MXene nanomaterials mediating the proliferation and early differentiation of cells. Researchers assessed the osteogenic activity of MXene on human Mesenchymal Stem Cells (hMSCs) with cell culture medium containing different concentrations of MXene 92 . When the concentration was <20 μg/ml, hMSCs showed distinct proliferation and osteogenic differentiation activity.…”

Section: Applications Of Mxene Nanomaterials In Tissue Engineering An...mentioning

confidence: 99%

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Zhong

Huang

Feng

et al. 2022

J Biomedical Materials Res

View full text Add to dashboard Cite

MXene, as a new two‐dimensional nanomaterial, is endowed with lots of particular properties, such as large surface area, excellent conductivity, biocompatibility, biodegradability, hydrophilicity, antibacterial activity, and so on. In the past few years, MXene nanomaterials have become a rising star in biomedical fields including biological imaging, tumor diagnosis, biosensor, and tissue engineering. In this review, we sum up the recent applications of MXene nanomaterials in the field of tissue engineering and regeneration. First, we briefly introduced the synthesis and surface modification engineering of MXene. Then we focused on the application and development of MXene and MXene‐based composites in skin, bone, nerve and heart tissue engineering. Uniquely, we also paid attention to some research on MXene with few achievements at present but might become a new trend in tissue engineering and regeneration in the future. Finally, this paper will also discuss several challenges faced by MXene nanomaterials in the clinical application of tissue engineering.

show abstract

Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells

Cited by 24 publications

References 42 publications

Safety Assessment of 2D MXenes: In Vitro and In Vivo

Safety Assessment of 2D MXenes: In Vitro and In Vivo

Ternary MXene-loaded PLCL/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Contact Info

Product

Resources

About