Stroke of the substance nigra and parkinsonism as first manifestation of systemic lupus erythematosus

San-Juan, Daniel; Rodríguez-Ortiz, Ulises

doi:10.1016/j.parkreldis.2007.08.001

Cited by 19 publications

(11 citation statements)

References 7 publications

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“…3 Since then, only about 30 NPSLE cases with parkinsonism have been reported to date (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Autoantibodies and immune-mediated vasculopathy was suggested in the pathogenesis of parkinsonism in NPSLE. 20 Kunas et al 4 found antibodies to dopaminergic cells in serum from the NPSLE patients manifested with parkinsonism.…”

Section: Discussionmentioning

confidence: 99%

Parkinsonism as a Manifestation of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report and Literature Review

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Parkinsonism as a Manifestation of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report and Literature Review

et al. 2015

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“…Although the exact etiology is unknown, VP is usually secondary to microvascular occlusive episodes typically localized to basal ganglia, including SN and striatum (Akyol et al, 2006; Vaamonde et al, 2007; Orta Daniel and Ulises, 2008). Vasospasm has been considered as a possible precipitating cause of the disease (Lammie, 2000).…”

Section: Discussionmentioning

confidence: 99%

Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations

Muñetón-Gómez¹,

Doncel‐Pérez²,

Fernández³

et al. 2012

Front. Cell. Neurosci.

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The increased risk and prevalence of lacunar stroke and Parkinson's disease (PD) makes the search for better experimental models an important requirement for translational research. In this study we assess ischemic damage of the nigrostriatal pathway in a model of lacunar stroke evoked by damaging the perforating arteries in the territory of the substantia nigra (SN) of the rat after stereotaxic administration of endothelin-1 (ET-1), a potent vasoconstrictor peptide. We hypothesized that transplantation of neural stem cells (NSCs) with the capacity of differentiating into diverse cell types such as neurons and glia, but with limited proliferation potential, would constitute an alternative and/or adjuvant therapy for lacunar stroke. These cells showed neuritogenic activity in vitro and a high potential for neural differentiation. Light and electron microscopy immunocytochemistry was used to characterize GFP-positive neurons derived from the transplants. 48 h after ET-1 injection, we characterized an area of selective degeneration of dopaminergic neurons within the nigrostriatal pathway characterized with tissue necrosis and glial scar formation, with subsequent behavioral signs of Parkinsonism. Light microscopy showed that grafted cells within the striatal infarction zone differentiated with a high yield into mature glial cells (GFAP-positive) and neuron types present in the normal striatum. Electron microscopy revealed that NSCs-derived neurons integrated into the host circuitry establishing synaptic contacts, mostly of the asymmetric type. Astrocytes were closely associated with normal small-sized blood vessels in the area of infarct, suggesting a possible role in the regulation of the blood brain barrier and angiogenesis. Our results encourage the use of NSCs as a cell-replacement therapy for the treatment of human vascular Parkinsonism.

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“…This was the pioneer case report in the literature secondary to vasculitis in a patient with SLE 7. A study has been done to find the relevance of cognitive dysfunction among patients with SLE who never displayed major neuropsychiatric manifestations.…”

Section: Discussionmentioning

confidence: 99%

Tumefactive demyelination associated with systemic lupus erythematosus

Verma

Arya²

2012

Case Reports

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Systemic lupus erythematosus (SLE) is a chronic inflammatory multi-system disease characterised by varied clinical manifestation and immunological abnormalities. The clinical presentation of the disorder has wide spectra, from an asymptomatic presentation to a severe life-threatening disease affecting several organs. The sole manifestation of lupus erythematosus could be neurological syndrome, where diagnosis of SLE is difficult to establish. The authors intended to report a young female, who initially developed left-sided hemiparesis due to tumefactive demyelination, later on diagnosed as case of SLE. The association of tumefactive demyelination and SLE has not been previously reported in the literature.

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Stroke of the substance nigra and parkinsonism as first manifestation of systemic lupus erythematosus

Cited by 19 publications

References 7 publications

Parkinsonism as a Manifestation of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report and Literature Review

Parkinsonism as a Manifestation of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report and Literature Review

Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations

Tumefactive demyelination associated with systemic lupus erythematosus

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