Stress and opioids: Role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference

Bali, Anjana; Randhawa, Puneet Kaur; Jaggi, Amteshwar Singh

doi:10.1016/j.neubiorev.2014.12.018

Cited by 94 publications

(60 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High Penk expression rate observed in D2 316 neurons ( Fig. 3a; Supplemental Table S1) pinpoints D2 MSNs entity as a major neuroendocrine response 317 body in dorsal striatum previously reported in (Dunn et al 2012;Bali et al 2015;Belujon and Grace 2015). 318…”

supporting

confidence: 64%

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Babenko

Galyamina

Rogozin

et al. 2019

Preprint

View full text Add to dashboard Cite

10A mouse model of chronic social conflicts was used to analyze dorsal striatum neurons implicated in 11 cAMP-mediated phosphorylation activation pathways specific for Medium Spiny Neurons (MSNs). Based on 12 expression correlation analysis, we succeeded in dissecting Drd1-and Drd2-dopaminoceptive neurons (D1 13 and D2, correspondingly) gene pathways. We also found that D1 neurons feature previously reported two 14 states, passive and active ones, represented in our analysis by distinct, negatively correlated gene clusters. 15The correlation based gene pathways strongly corroborate the phosphorylation cascades highlighted 16 in the previous studies, implying that the expression-based viewpoint corresponds to phosphorylation/ 17 dephosphorylation interplay in each type of neurons. Notably, D2 neurons showed the largest Ppp1r1b 18 (encoding DARPP-32) expression modulation impact, implying that Ppp1r1b expression dynamics is mostly 19 associated with neuroendocrine response mediated by Penk/Pdyn genes expression in D2 neurons. 20We observed that under defeat stress in chronic social conflicts mice exhibited reduced motor activity 21 as well as overall depression of dopamine-mediated MSNs activity, while aggressive mice exhibited motor 22 hyperactivity and an increase in both D1-active phase and D2 MSNs genes expression. 23Based on alternative transcript isoforms expression analysis, it was assumed that many genes (Drd1, 24 Adora1, Pde10, Ppp1r1b, Gnal), specifically those in D1 neurons, apparently remain transcriptionally 25 repressed via the reversible mechanism of promoter CpG island silencing, resulting in alternative promoter 26 usage following profound reduction in their expression rate. 27 Significance statement28 Medium Spiny Neurons (MSNs) comprise the main body of dorsal striatum neurons and represent 29 dopaminoceptive GABAergic neurons. The cAMP-mediated cascade of excitation and inhibition responses 30involved in dopaminergic neurotransmission is crucial for neuroscience research due to its involvement in the 31 motor and behavioral functions. In particular, all types of addictions are related to MSNs. Shedding the light 32 on the mechanics of the above-mentioned cascade is of primary importance for this research domain. In this 33 paper MSNs steady states will be elucidated based on pooled tissue RNA-Seq data not explicitly outlined 34 before and connected with dynamic dopamine neurotransmission cycles. 35

show abstract

supporting

confidence: 64%

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Babenko

Galyamina

Rogozin

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Synchronized actions, a component typical of collective rituals, have been found to lead to increased endorphin release in dancers (Tarr, Launay, Cohen, & Dunbar, 2015) and musical performers (Weinstein, Launay, Pearce, Dunbar, & Stewart, 2016). In turn, increased endorphin release plays a key role in stress-reduction (Bali, Randhawa, & Jaggi, 2015). When the All Blacks are performing their war cry and dance in unison, they are not only striking fear in the hearts of their opponents, but also bolstering their physiological resources to respond to stressors.…”

Section: Social Capitalmentioning

confidence: 99%

Collective rituals in team sports: Implications for team resilience and communal coping

Bonk

Leprince

Tamminen

et al. 2019

Mov Sport Sci/Sci Mot

View full text Add to dashboard Cite

Many sports teams engage in collective rituals (e.g., the New Zealand All Blacks' haka). While the concept has been studied extensively in other fields (e.g., social psychology and cultural anthropology), literature on collective rituals specific to sport is limited. Leveraging theoretical positions and empirical findings from across the human and social sciences, the application of an existing definition of collective ritual in team sports is explored. Complementary research is suggestive of a potential link between collective rituals and two growing topics of interest in group dynamics, namely, team resilience and communal coping. Collective rituals can bolster team resilience by strengthening the group structure and increasing a team's social capital. They can also serve as communal coping strategies, helping to manage team stressors as they arise. However, at the extremes, collective rituals can become problematic. Over-reliance and abusive rites of passage (i.e., hazing) are considered. Potential applied implications and future research directions in sport psychology are then discussed. Résumé --Les rituels collectifs : implications pour la résilience et le coping des équipes sportives. De nombreuses équipes sportives s'engagent dans des rituels collectifs (e.g., le haka des All Blacks). Bien que ce concept ait été étudié plus largement dans d'autres champs que la psychologie du sport (e.g., la psychologie sociale, l'anthropologie culturelle), la littérature sur les rituels collectifs spécifiques au contexte sportif est limitée. L'application d'une définition existante des rituels collectifs dans les sports d'équipe est ici explorée au travers d'une recension des cadres théoriques et des résultats empiriques issus de la littérature en sciences humaines et sociales. Des liens potentiels sont également envisagés entre les rituels collectifs et deux cadres théoriques dont l'intérêt en psychologie du sport est grandissant¦: la résilience d'équipe et la gestion collective du stress. Les rituels collectifs pourraient ainsi jouer un rôle dans la résilience d'équipe en renforçant la structure du groupe et son capital social. Ils pourraient également être utilisés par l'équipe comme stratégie collective de gestion du stress. En revanche, à l'opposé, les rituels collectifs peuvent dans certaines situations devenir problématiques, notamment la dépendance excessive et les rites de passage abusifs (i.e., le bizutage). Enfin, des implications pratiques et des perspectives de recherches prometteuses sont évoquées pour étudier les rituels collectifs dans le contexte sportif.

show abstract

“…[4][5][6] Cannabinoids have been well-documented for both their addictive effects and the harmfulness of their abuse. 7) Although the rewarding effect of cannabinoids, for example, Δ9-tetrahydrocannabinol (Δ9-THC), HU210, and other cannabinoid agonists, has been studied using the CPP paradigm, the results of these test are controversial.…”

Section: Cannabinoid-elicited Conditioned Place Preference In a Modifiedmentioning

confidence: 99%

Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm

Liu

Zheng

Qian

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cannabinoids using the conditioned place preference (CPP) model. Here, we optimized conditions for establishing CPP with the synthetic cannabinoid HU210 intraperitoneally administered at a high dose. We found that the natural place preference of rats could be exploited for establishing a biased CPP model, and that the adverse effect of HU210 could be ameliorated by adding four daily pre-injections before the conditioning program. Thus, 0.1 mg/kg HU210 induced CPP when pre-injections were administered before traditional conditioning with HU210 administration paired with the non-preferred compartment. The present study provides a useful CPP model for behavioral measurement of the rewarding effects of cannabinoids.Key words cannabinoid; conditioned place preference (CPP); drug reward Psychotropic drugs are characterized by their ability to elicit a rewarding effect, which eventually leads to abuse and addiction.1) Behavioral testing of animals is the classic approach for monitoring the rewarding effects of these drugs and is indispensable for dissecting the mechanisms underlying drug addiction.2,3) The conditioned place preference (CPP) model detects the rewarding effect of drugs after a conditioning procedure that builds an enforced connection between the motivational effect of addictive drugs and the place where the drug is administered.4) The CPP model is among the most popular paradigms for drug reward research and has been used in numerous studies examining many addictive drugs. [4][5][6] Cannabinoids have been well-documented for both their addictive effects and the harmfulness of their abuse. 7) Although the rewarding effect of cannabinoids, for example, Δ9-tetrahydrocannabinol (Δ9-THC), HU210, and other cannabinoid agonists, has been studied using the CPP paradigm, the results of these test are controversial. 3,6,8) This controversy may reflect the multiple experimental factors that affect the outcome of drug-place coupling, and the involvement of different brain regions and neurotransmitters, including the ventral tegmental area dopamine (DA) neurons as well as the glutamatergic and γ-aminobutyric acid (GABA)ergic inputs to the nucleus accumbens and ventral tegmental area, in the neural circuitry of cannabinoid reward. [9][10][11] In addition, the potential adverse effects on learning and memory and the reported anxiolytic property of cannabinoids may also underlie these discrepancies. 12,13) In the present study, the potential factors that may affect cannabinoid CPP models, such as cannabinoid doses, animal strains, and conditioning protocols, were considered and analyzed. We found CPP in response to cannabinoid administration after drug pre-injections combined with a biased protocol design. The ...

show abstract

Stress and opioids: Role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference

Cited by 94 publications

References 125 publications

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Collective rituals in team sports: Implications for team resilience and communal coping

Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm

Contact Info

Product

Resources

About