Streptophenazines I–L from Streptomyces sp. BCC21835

Bunbamrung, Nantiya; Dramae, Aibrohim; Srichomthong, Kitlada; Supothina, Sumalee; Pittayakhajonwut, Pattama

doi:10.1016/j.phytol.2014.08.011

Cited by 15 publications

(13 citation statements)

References 10 publications

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“…Streptophenazines 12-14, 17, and 18 showed a wide range of antibacterial activity against both Gram-positive and Gram-negative bacteria, while compounds 15, 16, and 19 were only against B. subtilis [18]. In addition, streptophenazine B exhibited weak cytotoxicity against both cancer cells and normal cells [19].…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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Section: Alkaloidsmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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“…CNB-091. Refactoring of the spz cluster resulted in tremendous structural diversity of the streptophenazine suite of natural products, PDC-derived phenazines with variable alkyl side chains isolated from Streptomyces bacteria (Bunbamrung et al, 2014;Kunz et al, 2014;Liang et al, 2017;Mitova et al, 2008). Our refactoring efforts resulted in the production of previously unseen N-formylglycine analogs with antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry

Bauman

Murata

et al. 2019

Cell Chemical Biology

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“…Streptomyces gramineus (386) spectrum showed a signal related to the compound diacarnoxide-A (RT=11.67, m/z= 408.6), which has been reported with cytotoxic activity against prostate cancer (PC3) and breast cancer (MDA-MB231) by Jingqiu et al [ 40 ]. LC-MS analysis showed the possible presence of Streptophenazine I (RT=17.01; m/z= 453.2 (M+H) + ) in the organic extract of Streptomyces psammoticus (519), which has been reported by Bunbamrung et al with cytotoxic activity against breast (MCF-7) and lung cancer (NCI-H187) [ 41 ].…”

Section: Discussionmentioning

confidence: 90%

Optimization of the Cytotoxic Activity of Three Streptomyces Strains Isolated from Guaviare River Sediments (Colombia, South America)

Ramírez-Rodríguez

Stepanian-Martinez

Morales-González

et al. 2018

BioMed Research International

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Three Streptomyces strains isolated from Guaviare sediments (Colombia, South America) with cytotoxic activity against prostate cancer (PC3), breast cancer (MDA-MB-231), and lung cancer (A549) line cells were studied. The present investigation reveals the enhancement of the cytotoxic activity evaluating different values of pH, carbon sources (sucrose, glucose, xylose, maltose, and starch), and nitrogen sources (malt extract, yeast extract, meat extract, peptone, and potassium nitrate). Based on the response surface methodology, the isolates Streptomyces aburaviensis (73) had the maximum activity for lung cancer (IC50= 25.00 ± 1.86 ppm) with 4% of yeast extract, 3% of starch, and a pH value of 7. Streptomyces gramineus (386) had the maximum activity against prostate cancer (IC50= 6.14 ± 2.07 ppm) with 5% of malt extract, 3% of glucose, and a pH value of 6. Finally, Streptomyces psammoticus (519) had the maximum activity against breast cancer (IC50= 35.53 ± 2.71 ppm) with 1% of yeast extract, 4% of starch, and a pH 8. The results suggest that the ethyl acetate extracts from isolates Streptomyces aburaviensis (73), Streptomyces gramineus (386), and Streptomyces psammoticus (519) have a potential for use in pharmaceuticals as cytotoxic agents.

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Streptophenazines I–L from Streptomyces sp. BCC21835

Cited by 15 publications

References 10 publications

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products from Actinomycetes Associated with Marine Organisms

Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry

Optimization of the Cytotoxic Activity of Three Streptomyces Strains Isolated from Guaviare River Sediments (Colombia, South America)

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