Strategies to design antimicrobial contact lenses and contact lens cases

Xiao, Amy; Dhand, Chetna; Leung, Chak Ming; Beuerman, Roger W.; Ramakrishna, Seeram; Lakshminarayanan, Rajamani

doi:10.1039/c7tb03136j

Cited by 58 publications

(67 citation statements)

References 109 publications

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“…A review was recently published by Xiao et al. [ 14 ] on various chemical strategies and techniques used for the design of antimicrobial contact lenses. Spallholz et al.…”

Section: Introductionmentioning

confidence: 99%

Novel Antimicrobial Coating on Silicone Contact Lens Using Glycidyl Methacrylate and Polyethyleneimine Based Polymers

Pillai

Reghu

Vikhe

et al. 2020

Macromol. Rapid Commun.

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Contact lenses are medical devices commonly used to correct refractive errors and to maintain ocular health. Microorganisms such as bacteria that grow on the lens surface cause irritation to the eyes and can even cause loss of vision. In this paper, two different coating strategies are employed to form an efficient antimicrobial coating on contact lenses. In the first method, a presynthesized copolymer of polyethyleneimine‐graft‐polyethylene glycol methacrylate (PEI‐PEGMA) is used and the coated lenses show antimicrobial activity (in vitro) against methicillin‐resistant Staphylococcus aureus (MRSA) bacteria with killing efficacy >99.99% and log reduction of 5.1 and proxy host cell viability of 79%. In the second method, commercially available monomers/polymers such as glycidyl methacrylate (GMA), sulfobetaine methacrylate, and polyethyleneimine are used. A typical formulation consisting of 1% GMA shows antibacterial activity against MRSA with killing efficacy >99.99% and log reduction of 6.3. Proxy host cell viability for the coated lenses is found to be 90% indicating that the coating is nontoxic. Antibacterial coating reported here is very effective in killing gram‐positive bacteria such as MRSA and S. aureus. The second method using commercially available monomers/polymers involving a simple coating procedure is also easily scalable.

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“…A review was recently published by Xiao et al. [ 14 ] on various chemical strategies and techniques used for the design of antimicrobial contact lenses. Spallholz et al.…”

Section: Introductionmentioning

confidence: 99%

Novel Antimicrobial Coating on Silicone Contact Lens Using Glycidyl Methacrylate and Polyethyleneimine Based Polymers

Pillai

Reghu

Vikhe

et al. 2020

Macromol. Rapid Commun.

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“…So far, a threshold defining an acceptable contamination level has not been identified. Novel case designs to reduce microbial contamination are being studied . Contact lenses handled inappropriately can adversely affect most anterior ocular structures .…”

Section: Contamination In Contact Lensesmentioning

confidence: 99%

“…Novel case designs to reduce microbial contamination are being studied . Contact lenses handled inappropriately can adversely affect most anterior ocular structures . The most frequent complications based on the eye site are summarized in Table 10 .…”

Section: Contamination In Contact Lensesmentioning

confidence: 99%

“…Silver impregnated lens cases and selenium lens cases have been designed with antimicrobial purposes . Other methods have been investigated for prevention and disinfection purposes, including the use of free‐radical producing agents, quorum‐sensing blockers, antimicrobial peptides, and nonsteroidal anti‐inflammatory drugs . To minimize microbial contamination, hygiene measures have to be taken.…”

Section: Contamination In Contact Lensesmentioning

confidence: 99%

See 1 more Smart Citation

Contact Lens Technology: From Fundamentals to Applications

Moreddu

Vigolo

Yetisen

2019

Adv Healthcare Materials

175

171

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Contact lenses are ocular prosthetic devices used by over 150 million people worldwide. Primary applications of contact lenses include vision correction, therapeutics, and cosmetics. Contact lens materials have significantly evolved over time to minimize adverse effects associated with contact lens wearing, to maintain a regular corneal metabolism, and to preserve tear film stability. This article encompasses contact lens technology, including materials, chemical and physical properties, manufacturing processes, microbial contamination, and ocular complications. The function and the composition of the tear fluid are discussed to assess its potential as a diagnostic media. The regulatory standards of contact lens devices with regard to biocompatibility and contact lens market are presented. Future prospects in contact lens technology are evaluated, with particular interest given to theranostic applications for in situ continuous monitoring the ocular physiology.

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“…12 In addition to the above-mentioned biological properties, zwitterionic sulfobetaine polymers are generally thermosensitive in aqueous solutions and exhibit upper critical solution temperature (UCST) phase transitions. [13][14][15] The zwitterionic betaine hydrogels, formed by virtue of a strong ability of zwitterionic moieties to bind water molecules, will have various potential applications, such as so contact lenses, 16,17 wound dressing, 3,18,19 drug release [20][21][22] and non-fouling materials. 23,24 It implies that zwitterionic betaine hydrogels will hold great application potentials as biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Self-healing zwitterionic sulfobetaine nanocomposite hydrogels with good mechanical properties

Lin

Zeng

et al. 2019

RSC Adv.

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Strategies to design antimicrobial contact lenses and contact lens cases

Abstract: Different strategies to design antimicrobial contact lenses and contact lens cases.

Cited by 58 publications

References 109 publications

Novel Antimicrobial Coating on Silicone Contact Lens Using Glycidyl Methacrylate and Polyethyleneimine Based Polymers

Novel Antimicrobial Coating on Silicone Contact Lens Using Glycidyl Methacrylate and Polyethyleneimine Based Polymers

Contact Lens Technology: From Fundamentals to Applications

Self-healing zwitterionic sulfobetaine nanocomposite hydrogels with good mechanical properties

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