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BackgroundNumerous techniques and materials are available for increasing the dorsal height and length of the nose. Microautologous fat transplantation (MAFT) may be an appropriate strategy for augmentation rhinoplasty.ObjectivesThe authors sought to determine the long-term results of MAFT with the so-called one-third maneuver in Asian patients who underwent augmentation rhinoplasty.MethodsA total of 198 patients who underwent primary augmentation rhinoplasty with MAFT were evaluated in a retrospective study. Fat was harvested by liposuction and was processed and refined by centrifugation. Minute parcels of purified fat were transplanted to the nasal dorsum with a MAFT-Gun. Patient satisfaction was scored with a 5-point Likert scale, and aesthetic outcomes were validated with pre- and postoperative photographs.ResultsThe mean age of the patients was 45.5 years. The mean operating time for MAFT was 25 minutes, and patients underwent 1-3 MAFT sessions. The mean volume of fat delivered per session was 3.4 mL (range, 2.0-5.5 mL). Patients received follow-up for an average of 19 months (range, 6-42 months). Overall, 125 of 198 patients (63.1%) indicated that they were satisfied with the results of 1-3 sessions of MAFT. There were no major complications.ConclusionsThe results of this study support MAFT as an appropriate fat-transfer strategy for Asian patients undergoing primary augmentation rhinoplasty.Level of Evidence: 4 Therapeutic

MAFT has changed the concept of fat grafting, from an operation with unpredictable clinical results to an easy and reliable procedure. MAFT demonstrated high patient satisfaction with long-term results and is an effective approach to rejuvenate the dorsal surface of the hand.

Diabetes mellitus (DM) causes impaired wound healing by affecting one or more of the biological mechanisms of hemostasis, inflammation, proliferation, and remodeling and a large number of cell types, extracellular components, growth factors, and cytokines. Interventions targeted toward these mechanisms might accelerate the wound healing process. To evaluate the wound healing efficacy of supercritical carbon dioxide (scCO2)-decellularized porcine acellular dermal matrix (ADM) combined with autologous adipose-derived stem cells (ASCs) in streptozotocin (STZ)-induced DM rats. DM was induced by injecting rats with STZ; dorsal full-thickness skin (5 × 5 cm 2) was created and treated with and without ASCs-scCO2-treated ADM to evaluate the wound healing rate through histological examination, fluorescence microscopic observation, and immunohistochemical analysis. In the present study, complete decellularization of the porcine dermal matrix was achieved through scCO2. Isolation of ASCs was conducted and evaluated using CD29 + /CD31 − /CD45 − /CD90 + markers in flow cytometry, which indicated that more than 90% of cells were ASCs. The percentage of cells labeled with CD29 + and CD90 + was found to be 97.50% and 99.69%, respectively. The wound healing rate increased in all groups relative to the group with the DM wound without treatment. DM wound treated with ADM-ASCs showed significantly higher (p < 0.01) wound healing rate than DM wound without treatment. ADM-ASC-treated rats showed significantly increased epidermal growth factor, Ki67, and prolyl 4-hydroxylase and significantly decreased CD45 compared with the group with the DM wound without treatment. The intervention comprising ADM decellularized from porcine skin by using scCO2 and ASCs was proven to improve diabetic wound healing. ADM-ASCs had a positive effect on epidermal regeneration, anti-inflammation, collagen production and processing, and cell proliferation; thus, it accelerated wound healing.

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Here we have obtained a thermoresponsive three-dimensional (3D) polyurethane (PU) sponge with temperature-controlled superwettability. First, silanization was used to enhance the surface roughness of the PU sponge and reactive vinyl groups were provided. We then grafted a polyisopropylacrylamide (PNIPAAm) hydrogel to the PU skeleton, resulting in the preparation of a temperature-responsive 3D PU material showing useful oil−water separation performance. The surface morphology, chemical composition, and wettability of the prepared modified PU sponge were clarified. The surface wettability of the modified sponge changed with temperature. Under ambient conditions with a temperature of 25 °C, which is lower than the low critical solution temperature of PNIPAAm (LCST, about 32 °C), the product showed superhydrophilicity in air and superoleophobicity under water, while when the outside temperature (45 °C) became higher than the LCST, the product changed to show high hydrophobicity in air and superlipophilicity under water. After 8 cycles of temperature variation, the product still showed impressive responsiveness. In addition to the smart responsive properties, the modified PU sponge could absorb and automatically desorb oil at 45 and 20 °C, respectively, showing good oil−water separation ability, together with the capability of oil recycling.

Compared to standard-dose rivaroxaban, low-dose rivaroxaban in Asian patients with AF was associated with similar risks of thromboembolism and bleeding except myocardial infarction.