Stopped-flow chemiluminescence spectrometry to improve the determination of pencillins based on the luminol-iodine reaction

Ventura, Sebastián; Silva, Manuel; Pérez‐Bendito, Dolores

doi:10.1016/0003-2670(92)85056-c

Cited by 22 publications

(10 citation statements)

References 30 publications

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“…Kinetic information is derived from the whole profile (rise and decay rates) and can be related to the analyte concentration with higher precision and selectivity than those provided by the height or area under the emissiontime curve. 96 Heterogeneous systems, where any of the reactants involved in the chemiluminescent process is physically or chemically immobilized onto a solid support, are also of a high analytical interest. 43 The chemiluminescence emission depends both on the reaction kinetics and on the efficiency of the mass transfer processes that come into play when the reactants are brought into contact.…”

Section: Continuous-¯ow Methodsmentioning

confidence: 99%

Flow‐chemiluminescence: a growing modality of pharmaceutical analysis

2001

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Section: Continuous-¯ow Methodsmentioning

confidence: 99%

Flow‐chemiluminescence: a growing modality of pharmaceutical analysis

2001

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“…The light generated in the reaction between luminal and iodine was used for the indirect stopped flow CL spectrometric determination of penicillins (PEN-G, AMP, AMO, CARB and TIC) based on their inhibitory effects on this reaction [108].…”

Section: Nonchromatographic Techniquesmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

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“…[6][7][8][9][10][11][12] These included an enhancement of chemiluminescence using a luminol-hydrogen peroxide and/or a cobalt(II) reaction, an inhibition of chemiluminescence on the luminol-iodine reaction and a chemiluminescence following oxidation by potassium superoxide.…”

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confidence: 99%