Chemiluminescence Determination on a Luminol Reaction of β-Lactam Antibiotics by FIA

Abstract

Chemiluminescence methods have been widely used in the analysis of chemical and biological samples by flow injection analysis (FIA) and liquid chromatography with chemiluminescence detection, and several reviews have also been reported concerning the application of chemiluminescence in chemical analysis.

Cetyltrimethylammonium Bromide-Enhanced Chemiluminescence Determination of Uric Acid Using a Luminol-Hexacyanoferrate(III)-Hexacyanoferrate(II) System

“…These results indicated that the dissolved oxygen played an important role in the reaction, which was in agreement with several reports. 9,[22][23][24][25][26][27][28] It is well known that the type of species has great effect on its CL intensity. Our experiments indicated that molecular species of uric acid enhanced CL intensity markedly.…”

Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis

“…LC/MS methods [17][18][19] have been developed for residue analysis of ␤-lactam antibiotics in bovine milk and tissues. Determination of ␤-lactam antibiotics with luminol chemiluminescence has also already been reported [20,21]. The mechanism of the chemiluminescence consists of the reaction between luminol and oxidized species that are generated during degradation of ␤-lactam antibiotics in alkaline solution, and its quantitative response has been demonstrated [21].…”

Flow injection chemiluminescence determination of cefadroxil using potassium permanganate and formaldehyde system

“…However, they often suffer from a variety of limitations. But analytical methods applying chemiluminescence (CL) [16][17][18][19][20][21][22][23][24][25][26][27] provide many advantages for determining pharmaceuticals such as high sensitivity, high selectivity, small amount of chemical consumption, instrumental simplicity (no monochromator required) and speed of in signal detection (∼0.1-10 s). Since many CL reactions are very fast, they give rise to imprecise measurements as a result of irreproducible mixing of sample and reagents, but the reproducibility and selectivity of CL analysis can be improved by combination with flow injection analysis (FIA).…”