Stop eating plastic, molecular signaling of bisphenol A in breast cancer

Shafei, Ayman; Matbouly, M.E.; Mostafa, Ezzat; Sannat, Salah Al; Abdelrahman, Mahmoud A. E.; Lewis, Bola; Muhammad, Badr; Mohamed, Shaima Shaban; Mostafa, Randa

doi:10.1007/s11356-018-2540-y

Cited by 42 publications

(11 citation statements)

References 60 publications

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“…Additionally, a ten year study comparing BPA levels in amniotic fluid between pregnant mothers with normal and abnormal karyotype fetuses highlighted that mothers with abnormal karyotype fetuses had higher levels of BPA concentrations in amniotic fluid, in comparison to pregnant women with normal karyotype fetuses. Therefore, these findings highlight the distorting potential BPA has in DNA stability and carcinogenesis induction 56 .…”

Section: A Comparison Of Various Studies Assessing Genotoxic and Clastogenic Potential Of Bpamentioning

confidence: 79%

Genotoxicity and Clastogenicity of Bisphenol A

Adelina Ismaili,

Flaka Pasha

2021

Indian Journal of Forensic Medicine & Toxicology

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Objectives: This review represents a critical and constructive analysis of literature in the content of genotoxicity and clastogenicity of Bisphenol A. The review is generated through summary, classification, analysis and comparison of already existing material and researches on field.Methods: Databases as Scopus, PubMed, Medline and Web of Science were used to extract data for the review. Search terms like "Bisphenol A", "endocrine disruptors","clastogenicity" and "genotoxicity" were inquired. Out of 350 research articles screened, 60 most relevant studies are included in this review. Conclusion :This review highlights the endocrine disrupting potential of Bisphenol A, thus leading to genotoxic and clastogenic events, especially impacting fragile categories like pregnant women, infants and children. BPA induces oxidative stress, inflammatory response, DNA strand break, chromosome aberrations and epigenetic changes, affecting neuroendocrine and reproductive system, metabolism, immunity, liver function, and increases the incidence of thyroid, liver, breast, uterine and ovary cancer.We can conclude that human exposure to BPA, as one of the leading environmental contaminants, represents a major global issue. BPA by its genotoxic and clastogenic potential can be debilitating for human health. Further research on field considering BPA distribution, varying exposure rates, racial disparities and interspecies differences, should be conducted. Avoiding exposure to BPA and finding safer alternatives to refine, reduce or replace BPA in market should remain a priority.

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Section: A Comparison Of Various Studies Assessing Genotoxic and Clastogenic Potential Of Bpamentioning

confidence: 79%

Genotoxicity and Clastogenicity of Bisphenol A

Adelina Ismaili,

Flaka Pasha

2021

Indian Journal of Forensic Medicine & Toxicology

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“…With the lack of accessibility to a hospital and the cost of diagnosis, many women are unwilling to seek a diagnosis due to their socio-economic status. Improper treatment, poverty, and late diagnosis are also contributing factors [ 37 , 38 ]. A report published by NICRH indicated that illiterate housewives were highly prone to be affected by breast cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Women living in urban areas are different from women in rural areas in their reproductive behavior; they are reluctant to marry, have children, or breastfeed [ 39 ]. The use of chemicals in dermatological products and crop production and bisphenol A in plastic materials is changing the secretion of estrogen, also leading to breast cancer development [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Studies of Different Cancer Diseases among Less-Developed Countries

2022

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Recently, the rate of cancer deaths in less-developed countries such as Bangladesh has significantly increased day by day, making it a major health issue. The most predominant types of cancers among the populations of less-developed countries (especially Bangladesh) are lung, throat, colon, gastric, ovarian, breast, and skin cancers. The mortality rate is increasing for both males and females. The main common factors are smoking, use of tobacco leaves, bacterial or viral infection, hereditary disorders, food adulterations, and environmental factors, which are highly responsible for the development of carcinoma in the young to adult population in this region. Raising consciousness among people regarding early diagnosis, decreasing the use of chemicals such as formalin for food preservation, and reducing environmental pollution such as arsenic as well as air pollution might help to reduce the number of deaths. Education and public campaigns can also reduce the intensity of cancer occurrence. Breast, esophagus, and cervical cancer are common diseases in less-developed countries such as Bangladesh.

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“…At the mechanistic level, a large number of in vivo and in vitro studies have highlighted the ability of BPA to disrupt several key signaling pathways that are known to be involved in breast cancer [19,40]. However, the direct involvement of BPA in breast cancer incidence is difficult to establish and remains controversial [26,41], owing possibly to the fact that different mechanisms are depicted in either ER-positive or -negative tumors, reflecting the variety of biological effects arising from exposure to BPA [20,28,42].…”

Section: Bpa Involvement In Breast Cancermentioning

confidence: 99%

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

Guyot¹,

Maguer-Satta²

2020

Breast Cancer Biology

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Endocrine disruptors interfere with endocrine-mediated regulations of cell or organ functions. Estrogens are one of the main hormones altered by endocrine disruptors like bisphenol A (BPA). Stem cells are active from embryogenesis to late stages of adult life. Their unique properties, such as an extended lifespan and low cycling features, render these cell privileged targets of long-term exposure to numerous factors. Therefore, stem cells are likely to be affected following exposure to endocrine disruptors. One of the major signaling pathways involved in stem cell regulation is the bone morphogenetic protein (BMP) pathway. The BMP pathway is known for its involvement in numerous physiological and pathophysiological processes. Exposure of human mammary stem cells to pollutants such as BPA initiates fundamental changes in stem cells, in particular by altering major elements of BMP signaling, such as receptor expression and localization. Lastly, BPA and its substitute bisphenol S (BPS) have similar impacts on BMP signaling despite their different ER-binding properties, supporting the hypothesis that their biological effects cannot be extrapolated only from their interaction with ERα66. We review recent discoveries in this field and discuss their implications for cancer diagnosis, prevention, and treatment, as well as their relevance for studies on endocrine disruptors.

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Stop eating plastic, molecular signaling of bisphenol A in breast cancer

Cited by 42 publications

References 60 publications

Genotoxicity and Clastogenicity of Bisphenol A

Genotoxicity and Clastogenicity of Bisphenol A

Comprehensive Studies of Different Cancer Diseases among Less-Developed Countries

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

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