Stokes-Correlometry Analysis of Biological Tissues With Polycrystalline Structure

Ushenko, Yu. A.; Sdobnov, Anton; Dubolazov, A. V.; Grytsiuk, Marta; Bykov, Alexander; Meglinski, Igor

doi:10.1109/jstqe.2018.2865443

Cited by 43 publications

(51 citation statements)

References 30 publications

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“…Thus, the diattenuation vectors for normal and various grades of precancer cervical tissue sections are found to be different nature addressing the differential attenuation of linear and circular polarizations of light. Stokes‐correlometry analysis of biological tissue with polycrystalline structures of rat kidney with normal and pathological condition has been performed for the diagnosis and detection of diabetes . The Stokes vector components (second and third components) deal with azimuth and ellipticity along with estimation of the polarization ellipticity through the fourth component of Stokes vector.…”

Section: Resultsmentioning

confidence: 99%

“…The Stokes vector components (second and third components) deal with azimuth and ellipticity along with estimation of the polarization ellipticity through the fourth component of Stokes vector. The normal and diabetic kidney samples are well differentiated through the Stokes‐correlometry parameters dealing with phase and modulus of the polarization inhomogeneous images for the kidney samples of both type of tissue where the phase shift change is observed due to the various size of the birefringent fibrils and their curvilinearity and shows the fractal nature of the specimen. In this study, the different nature of refractive index of the biological specimen for the linear, linear‐45 and circular polarization has not taken into consideration.…”

Section: Resultsmentioning

confidence: 99%

“…The chiral nature of the optically anisotropic stromal region (optically active collagen fibers) of cervical tissue is the origin of the circular birefringence. In several reports , the circular birefringence has been discussed by studying polycrystalline films of biological tissue and fluids as diagnostic parameters for various types of disease through different techniques and analytical methods. The estimation of the polarization–correlation parameters based on the spatial frequency analysis of linear and circular birefringence have been reported from the histological sections of cervical tissues with different pathological condition .…”

Section: Resultsmentioning

confidence: 99%

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Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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The mapping of diattenuation, polarizance and retardance vector (normalized Stokes vector) on Poincare sphere, evaluated from Mueller matrix of optically anisotropic stromal region of cervical tissues, is presented for cervical precancer detection and its staging. This reveals that the changes in the polarization states shown by these normalized Stokes vectors corresponds to the degradation of linearly arranged collagen fibers, breakage of the collagen cross links in the stromal region and change in the density of scattering sites when cervical cancer evolves. The distinct nature of real and imaginary parts of the refractive index for linear, linear-45 and circular polarization from the optically anisotropic stromal region underscore the various polarization structures of the connective tissue region which get modified during the pathological changes. It has been found that versatility of these vectors for normal and precancerous cervical tissue of various grades may be utilized as a key distinction for qualitative staging of cervical precancer tissue. Quantitative classification of precancerous stages of cervical precancer has been determined with 95%-100% sensitivity and 93%-100% specificity through the evaluation of linear and circular diattenuation, linear polarizance and linear birefringence from the components of the respective vectors. K E Y W O R D S cervical cancer, diattenuation vector, Mueller matrix, Poincare sphere, polarizance vector, retardance vector, stromal region

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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“…44 Therefore, the e®ects of optically anisotropic absorption are less pronounced in comparison with the mechanisms of phase anisotropy. (1,6), linear (2, 7) and circular (3,8) birefringence; histograms of the distribution of the phase anisotropy parameters (4,5,9,10) of polycrystalline synovial°uid¯lms of patients from group 3 (1)-(5) and group 4 (6)-(10).…”

Section: Polycrystalline Structure Of Synovial°u Id¯lmsmentioning

confidence: 99%

“…Traditionally, the diagnostics of phase-inhomogeneous object structures are based on the use of various optical techniques, such as spectroscopy, polarimetry, interferometry, etc. [1][2][3][4][5] Mueller-matrix polarimetry (MMP) of optical anisotropy of polydisperse biological objects is one of the most perspective and e®ective methods for diagnostics in biomedicine. 6 Recent developments and achievements in MMP for the diagnosis of pathological changes in tissues of various human organs have been presented in a number of reviews [7][8][9][10][11][12][13] and original [14][15][16][17] papers.…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fluids

Ушенко

Sdobnov

Mishalov

et al. 2019

J. Innov. Opt. Health Sci.

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Algorithms for reconstruction of linear and circular birefringence-dichroism of optically thin anisotropic biological layers are presented. The technique of Jones-matrix tomography of polycrystalline films of biological fluids of various human organs has been developed and experimentally tested. The coordinate distributions of phase and amplitude anisotropy of bile films and synovial fluid taken from the knee joint are determined and statistically analyzed. Criteria (statistical moments of 3rd and 4th orders) of differential diagnostics of early stages of cholelithiasis and septic arthritis of the knee joint with excellent balanced accuracy were determined. Data on the diagnostic efficiency of the Jones-matrix tomography method for polycrystalline plasma (liver disease), urine (albuminuria) and cytological smears (cervical cancer) are presented.

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Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Ivanov

Dremin

Bykov

et al. 2020

Journal of Biophotonics

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This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for non-invasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumour removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fibre laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

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Stokes-Correlometry Analysis of Biological Tissues With Polycrystalline Structure

Cited by 43 publications

References 30 publications

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fluids

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

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