Stimuli-sensitive Systems-an emerging delivery system for drugs

Bhardwaj, Ankur; Kumar, Lalit; Mehta, Shuchi; Mehta, Amol

doi:10.3109/21691401.2013.856016

Cited by 31 publications

(16 citation statements)

References 52 publications

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“…The use of stimuli-responsive systems for drug delivery has received increasing attention and mainly utilizes the special conditions of the tumor microenvironment, including a low pH, high temperature, and high glutathione (GSH) concentration, to achieve targeted drug delivery and release [24]. In this way, the use of stimuli-responsive systems not only decreases the drug dose and systemic toxicity but also weakens toxicity to normal tissues [25].…”

Section: Stimuli-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Stimuli-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…The increased lacrimation, reflux blinking and nasolacrimal drainage accounts for the rapid elimination of the drugs from the cul-de-sac [2,3]. Various formulations like ocular ointments, hydrogels, polymeric or ion-exchange resin based topical ocular inserts and in situ gel systems have been reported to improve the residence of the drugs in the pre-corneal space [6–9]. In situ hydrogels have better patient compliance unlike ocular ointments and inserts which causes blurred vision and grittiness influenced distressed blinking [8,10,11].…”

Section: Introductionmentioning

confidence: 99%

Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation

Janga

Tatke

Balguri

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered by short precorneal residence and limited transmembrane permeability of topically administered drugs. Hence, the current study was undertaken to fabricate the ion-sensitive in situ gels of natamycin (NT) bilosomes (NB) for efficient ocular delivery. The effect of cholesterol and sodium taurocholate proportion on the properties of the bilosomes were studied and the formulation with better physicochemical properties was optimized and utilized to derive the in situ gelling system (IG). The impact of type/composition of gelling agent on the formation and characteristics of the hydrogel was investigated. The hydrogel formed from IG with 0.3% w/v gellan gum showed optimal viscoelastic and adhesive characteristics. The ocular safety and cytocompatibility of NB and its IG was confirmed by corneal histology and in vitro cytotoxicity evaluation. A 6- to 9-fold enhancement in the transcorneal flux of NB demonstrated efficient ocular penetration of bilosomes. Moreover, the superior mean dose normalized NT levels in the ocular tissues of rabbits treated with optimized NB and IG illustrated the effectiveness of bilosomes loaded ion-sensitive in situ hydrogels as a potential platform for the improved and prolonged ocular pharmacotherapy.

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“…However, most of these drugs have some limitations, such as poor solubility, high toxicity, high dosage, poor stability, non-specific targeting, short live, and so on. Drug delivery systems have been used to overcome these limitations (Bhardwaj et al 2015, Orive et al 2003, Sharma et al 2016. By using controlled drug delivery systems, drugs can be used for defined periods of time with determined rates (Qui andPark 2012, Yoshida et al 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Drug delivery is a process which releases a specific bioactive agent to the target region with a constant rate (Bhardwaj et al 2015, Langer 1990, 1994, Orive et al 2003, Parveen et al 2012, Sharma et al 2016. New class of drugs are still discovering and testing for human use.…”

Section: Introductionmentioning

confidence: 99%

Controlled release of curcumin from poly(HEMA-MAPA) membrane

Caka

Türkcan

Uygun

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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In this work, poly(HEMA-MAPA) membranes were prepared by UV-polymerization technique. These membranes were characterized by SEM, FTIR, and swelling studies. Synthesized membranes had high porous structure. These membranes were used for controlled release of curcumin which is already used as folk remedy and used as drug for some certain diseases and cancers. Curcumin release was investigated for various pHs and temperatures. Optimum drug release yield was found to be as 70% at pH 7.4 and 37 °C within 2 h period. Time-depended release of curcumin was also investigated and its slow release from the membrane demonstrated within 48 h.

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Stimuli-sensitive Systems-an emerging delivery system for drugs

Cited by 31 publications

References 52 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation

Controlled release of curcumin from poly(HEMA-MAPA) membrane

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