Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Abstract

Diabetic wound infection is a common disease that has significantly reduced people's quality of life. Although tremendous achievements have been made in clinical treatment, the crucial challenge for diabetic infected...

Biomedical materials for wound dressing: recent advances and applications

“…1 Both acute and chronic wounds have a severely detrimental impact on the world's healthcare systems and economies. 3,4 In the United States, injury treatment costs about 50 billion dollars annually. 5 According to Medicare, a health insurance program, the cost of wound care for beneciaries ranges from 28.1 to 96.8 billion dollars per year, with surgical wounds and diabetic ulcers the most expensive, accounting for 38.3 and 18.7 billion dollars, respectively.…”

Amylase degradation enhanced NIR photothermal therapy and fluorescence imaging of bacterial biofilm infections

“…38 Due to the unique interactions between the biofilm and the host, the infected tissues usually present an acidic biofilm microenvironment (BIM), which makes MnO 2 NSs a potential BIM-responsive nanoplatform for the treatment of biofilm infections. 13,39,40 Thus, the loading of biofilm EPS-degrading enzymes and photothermal agents onto the surface of MnO 2 NSs is expected to achieve efficient removal of biofilms.…”

Nanohybrid Double Network Hydrogels Based on a Platinum Nanozyme Composite for Antimicrobial and Diabetic Wound Healing

“…Previous work suggested that modulation of the wound microenvironment will benefit chronic wound healing and indicates a new direction for treatment strategies for diabetic wounds. ,− Currently, a series of materials designed for diabetic wound characteristics provide new therapeutic tools, such as an injected nanolipid emulsion to regulate the local inflammatory microenvironment, nanomaterials loaded with glucose oxidase to regulate the high glucose level at the wound, hydrogels for drug release in response to the pH and high glucose environment at the wound to promote healing, and an antioxidant hydrogel designed for the accumulation of reactive oxygen species in wounds . Nanoparticles have unique advantages in regulating the microenvironment due to their multispecies enzymatic activity − and distinctive pH-dependent properties, such as selectively increasing H 2 O 2 concentration in the tumor microenvironment to improve tumor therapeutic efficacy, alleviating tumor hypoxia to enhance oxidative stress in TME, and maintaining a normal microenvironment to improve flap survival . Our previous work has shown that platinum nanoparticles (Pt NPs) possess multiple enzymatic activities such as glucose oxidase (GOD)-like, peroxidase-like (POD), oxidase (OXD)-like, catalase (CAT)-like, and superoxide dismutase (SOD)-like, which can perform a specific function in different stages of the wound pH environment.…”