Amylase degradation enhanced NIR photothermal therapy and fluorescence imaging of bacterial biofilm infections

Abstract

A two-dimensional theranostic nanoagent was developed for enzyme degradation enhanced photothermal therapy and fluorescence imaging of methicillin-resistant Staphylococcus aureus biofilm infections.

Nanomaterials for photothermal cancer therapy

“…[22][23][24] Indocyanine green (ICG) is a FDA-approved, watersoluble dye that has been widely used as a contrast agent in medical imaging and as a photosensitizer in PDT. 25 In recent years, ICG has also emerged as a promising organic photothermal conversion material for PTT. 26 Therefore, ICG can be used for PTT/PDT combined therapy.…”

Construction of mPt/ICG-αA nanoparticles with enhanced phototherapeutic activities for multidrug-resistant bacterial eradication and wound healing

“…Numerous studies have shown that enzymatic degradation of EPSs can remove restrictions on drug molecules in microhabitats and make microbes susceptible to anti-microbial agents. [31][32][33][34] Due to the excellent pH stability, thermo-stability, and biocompatibility, α-amylase (αA) is a promising enzyme candidate that can be used for bacterial infection treatment. 32 Previous studies have shown that antimicrobial materials containing α-amylase can effectively disrupt biofilms by hydrolyzing EPSs into oligosaccharides (e.g.…”

“…[31][32][33][34] Due to the excellent pH stability, thermo-stability, and biocompatibility, α-amylase (αA) is a promising enzyme candidate that can be used for bacterial infection treatment. 32 Previous studies have shown that antimicrobial materials containing α-amylase can effectively disrupt biofilms by hydrolyzing EPSs into oligosaccharides (e.g. glucose, maltose, etc.)…”

Photothermally Controlled Drug Release of Poly(d,l-lactide) Nanofibers Loaded with Indocyanine Green and Curcumin for Efficient Antimicrobial Photodynamic Therapy

“…Simultaneously, the bacterial load should be suppressed directly at the time of colonization not only to reduce the number of microorganisms but also to prevent biofilm formation [ 5 ]. Biofilms also delay wound healing enormously and usually have even higher resistance to antimicrobial agents, hence, accurate treatment with antibiotics or effective alternatives is necessary to prevent the development of antimicrobial resistance (AMR) [ 6 , 7 , 8 ].…”