Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study

Xia, Lunguo; Ma, Wudi; Zhou, Yifeng; Gui, Zhipeng; Yao, Aihua; Wang, Deping; Takemura, Akimichi; Uemura, Mamoru; Lin, Kailin; Xu, Yinghong

doi:10.1155/2019/8961409

Cited by 27 publications

(16 citation statements)

References 58 publications

(47 reference statements)

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“…The results confirm that the glass can degrade faster in dynamic conditions than in static ones. Although borate bioactive glasses have shown both mechanical and surface characteristic properties favorable for potential application in the biomedical area, most of the literature reports only results of in vivo or pre-clinical studies [ 42 , 45 , 142 , 143 , 144 , 145 ]. This is due to the fact that the area of bioactive borate glass science is still young and not sufficiently developed.…”

Section: Applications and Clinical Trialsmentioning

confidence: 99%

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

et al. 2021

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The use of bioactive glasses in dentistry, reconstructive surgery, and in the treatment of infections can be considered broadly beneficial based on the emerging literature about the potential bioactivity and biocompatibility of these materials, particularly with reference to Bioglass® 45S5, BonAlive® and 19-93B3 bioactive glasses. Several investigations have been performed (i) to obtain bioactive glasses in different forms, such as bulk materials, powders, composites, and porous scaffolds and (ii) to investigate their possible applications in the biomedical field. Although in vivo studies in animals provide us with an initial insight into the biological performance of these systems and represent an unavoidable phase to be performed before clinical trials, only clinical studies can demonstrate the behavior of these materials in the complex physiological human environment. This paper aims to carefully review the main published investigations dealing with clinical trials in order to better understand the performance of bioactive glasses, evaluate challenges, and provide an essential source of information for the tailoring of their design in future applications. Finally, the paper highlights the need for further research and for specific studies intended to assess the effect of some specific dissolution products from bioactive glasses, focusing on their osteogenic and angiogenic potential.

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Section: Applications and Clinical Trialsmentioning

confidence: 99%

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

et al. 2021

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“…In this study, a B-BG was obtained from boron which completely replaced sodium. Studies from previous articles have confirmed its osteoinductive aptitude and degradation characteristics (Xia et al, 2019;Deilmann et al, 2020;Houaoui et al, 2020;Li et al, 2020). Also, implants that were hard to degrade were described to cause long-term inflammatory reactions, and stress shielding occurs, which results in bone resorption and implant loosening due to mechanical properties that do not match that of the natural bone (Fedorowicz et al, 2007;Xu et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B2O3 (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO2. For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects.

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“…In particular, the VEGF overexpression was comparable with the one obtained by treating cells with particle suspensions of S53P4 BG82 and copper‐doped BG 81. When compared with composite biomaterials based on aliphatic polyesters, v‐PCL/CuChi12 performed better than PCL/boron‐containing BG16 and PLGA/collagen/ 64S BG composite films, both with and without Mg and Co doping 80. Possibly, this is, among other factors, also a consequence of the better proliferation substrate provided by electrospun fiber mats compared to a film.…”

Section: Resultsmentioning

confidence: 55%

“…At the end of the cell culture period (7 days after cell seeding), the vascular endothelial growth factor (VEGF) release from ST‐2 cells was measured. The quantification of VEGF, among several other parameters that could be monitored to characterize the angiogenic potential of copper, is generally considered the golden standard for the assessment of this property in biomaterials 16,73,80–82. In addition, ST‐2 cells are known to provide reliable results in terms of pro‐angiogenic behavior.…”

Section: Resultsmentioning

confidence: 99%

“…The results achieved with biomolecules are very encouraging. However, there are several issues concerning their clinical use, such as very high costs, questions about patient safety (e.g., immunogenicity, carcinogenicity), and difficulties in regulation and scale‐up 16,17. To date, the commercialization of growth factors and similar biomolecules for biomedical applications still appears prohibitively expensive and non‐viable on an industrial scale 14.…”

Section: Introductionmentioning

confidence: 99%

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Polycaprolactone Electrospun Fiber Mats Prepared Using Benign Solvents: Blending with Copper(II)‐Chitosan Increases the Secretion of Vascular Endothelial Growth Factor in a Bone Marrow Stromal Cell Line

Gritsch

Liverani

Lovell

et al. 2020

Macromolecular Bioscience

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Inducing the formation of new blood vessels (angiogenesis) is an essential requirement for successful tissue engineering. Approaches have been proposed to enhance angiogenesis using growth factors and other biomolecules; however, this approaches present drawbacks in terms of high cost and patient safety. Copper is known to effectively regulate angiogenesis and can offer a more cost‐effective alternative than the direct use of growth factors. With this study, a strategy to incorporate copper in electrospun fibrous scaffolds with pro‐angiogenic properties is presented. Polycaprolactone (PCL) and copper(II)‐chitosan are electrospun using benign solvents. The morphological and physicochemical properties of the fiber mats are investigated through scanning electron microscopy (SEM), static contact angle measurements, energy dispersive X‐ray, and Fourier‐transform infrared spectroscopies. Scaffold stability in phosphate buffered saline at 37 °C is monitored over 1 week. A bone marrow stromal cell line (ST‐2) is cultured for 7 days and its behavior is evaluated using SEM, fluorescence microscopy and a tetrazolium salt‐based colorimetric assay. Results confirm that PCL/copper(II)‐chitosan is suitable for electrospinning. The fiber mats are biocompatible and favor cell colonization and infiltration. Most notably, the angiogenic potential of PCL/copper(II)‐chitosan blends is confirmed by a three‐fold increase in VEGF secretion by ST‐2 cells in the presence of copper(II)‐chitosan.

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Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study

Cited by 27 publications

References 58 publications

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

Bioactive Glass Applications: A Literature Review of Human Clinical Trials

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Polycaprolactone Electrospun Fiber Mats Prepared Using Benign Solvents: Blending with Copper(II)‐Chitosan Increases the Secretion of Vascular Endothelial Growth Factor in a Bone Marrow Stromal Cell Line

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