Stimulation of Ethanol Metabolism Induced by Proline and Lysine Ingestion in Prolonged Ethanol-Administered Stroke-Prone Spontaneously Hypertensive Rats.

Abstract

SummaryThe influence of proline and lysine solution ingestion on ethanol metabolism after chronic oral ethanol administration was investigated in stroke-prone spontaneously hypertensive rats (SHRSP). Compared with rats that were not administered ethanol (control group), the prolonged ethanol-administered rats (EtOH group) showed little change in their blood ethanol levels, but a remarkable increase and slow appearance in the blood acetaldehyde levels after the oral administration of ethanol. When prolonged ethanol-administered rats ingested the proline solution (EtOH/Pro group), higher levels of blood ethanol continued. However, the increase in blood acetaldehyde levels was not observed in the EtOH/Pro group. In the case of prolonged ethanoladministered rats that ingested the lysine-containing solution (EtOH/Lys group), blood ethanol levels decreased and disappeared 4 h after the oral administration. An effect of lowered blood acetaldehyde levels was also observed. When prolonged ethanol-administered rats ingested both proline and lysine (EtOH/Pro+Lys group), the effect on blood ethanol levels was similar to that of rats that had ingested lysine only, and the influence on blood acetaldehyde was like that of rats that had only ingested proline. These results suggest that proline and lysine can regulate ethanol metabolism and the influence of proline on ethanol metabolism is different from that of lysine.

Preparation of Corn Peptide from Corn Gluten Meal and Its Administration Effect on Alcohol Metabolism in Stroke-Prone Spontaneously Hypertensive Rats.

“…It has been reported that the oxidation of ethanol proceeds in the presence of proline and lysine (11,(19)(20)(21) and that L-lysine lowers the blood ethanol concentration as a result of poor alcohol absorption or its raised urinary excretion in case of drinking (19,20). Yang et al (9) have described that the alcohol intake in rats increases when amino acids such as proline, lysine, and threonine are given together while drinking. Protein and amino acids are known to affect ethanol metabolism to some extent, but the effect of oligopeptides has not been investigated until now.…”

“…These observations suggest that the ingestion of amino acids may have nutritional and physiological effectiveness. Incidentally, Yang et al (9) reported that the ethanol intake in SHR-SP is increased by adding proline, lysine, or threonine to the alcohol solution, and that these amino acids surely regulate ethanol metabolism, although the influence of proline and lysine on ethanol metabolism differ. It has also been reported that ethanol metabolism is accelerated in the presence of amino acids such as glycine, serine, and methionine (10)(11)(12)(13), and that constant or high alcohol intake-caused impairment of health is ameliorated or relieved by doses of both alanine and glutamine (14).…”

Effect of Long-Term 'Corn Pepffde' Ingestion on Alcohol Metabolism in Stroke-Prone Spontaneously Hypertensive Rats with Alcohol Loading.

“…The supplementation of amino acids to heavily drunk animals may have important nutritional and physiological values, and avail to prevent malnutrition and metabolic disorder (6,7). In practice, the ingestion of proline and lysine depressed an increase in plasma aspartic acid aminotransaminase (GOT) activity but not in plasma alanine aminotransaminase (GPT) activity, even after long-term ethanol loading (8). Alanine and glutamine were also effective in improving alcoholic disorders (9).…”

The Effects of Corn Peptide Ingestion on Facilitating Alcohol Metabolism in Healthy Men

“…4 ) However, no studies have been done to investigate the mechanism of the effect on facilitating alcohol metabolism by which the intake of oligopeptide, rich in these amino acids, reduces the increase in blood ethanol level in rats or humans.…”