Effect of Long-Term 'Corn Pepffde' Ingestion on Alcohol Metabolism in Stroke-Prone Spontaneously Hypertensive Rats with Alcohol Loading.

Abstract

SummaryThe effect of long-term `corn peptide (CP)' ingestion on alcohol metabolism was investigated in stroke-prone spontaneously hyper tensive rats (SHR-SP) with alcohol loading. Long-term CP ingestion in the EtOH/CP group did not significantly increase plasma GOT and GPT activities but markedly increased hepatic ADH and ALDH activities. Intragastric CP administration prior to a dose of 1.0 g/kg ethanol signifi cantly lowered the blood ethanol concentration in SHR-SP which had been loaded with ethanol for a long time. Compared with non-loaded SHR-SP (control group), the rats loaded for a long time with ethanol (EtOH group) showed high concentrations of taurine, glycine and histi dine in the plasma. The plasma threonine and proline concentrations were significantly elevated by long-term CP ingestion (EtOH/CP group), but the plasma alanine concentration was rather decreased. These results suggest that short or long-term CP ingestion may enhance the alcohol metabolism within the body because of an increase in ADH and ALDH activities as well as the alleviation of alcohol-related hepatic injury.

Antioxidant Properties and Possible Mode of Action of Corn Protein Peptides and Zein Peptides

“…Glutamic acid, leucine, alanine and proline are rich in both CPS and ZPS. These results agreed with previous reports (Yamaguchi et al. 1996b, 1997; Li et al.…”

A Comprehensive Review of Corn Protein‐derived Bioactive Peptides: Production, Characterization, Bioactivities, and Transport Pathways

“…Many studies have been devoted to the preparation of new corn‐derived bioactive peptides to facilitate alcohol metabolism (Ma et al., ; Wang et al., ; Yu et al., ). Yamaguchi, Nishikiori, Nozaki, Ito, and Furukawa () found that long‐term intake of CPs could markedly increase hepatic ADH and ALDH activities, contributing to the transitions from alcohol to acetaldehyde and from acetaldehyde to acetate, respectively. CPs can supply the NAD + content by consuming Ala, Leu, and Pro, and slow the absorption rate of alcohol via the gastrointestinal membrane (Yamaguchi, Nishikiori, Ito, & Furukawa, ).…”

“…As shown in Figure , CPs facilitate alcohol metabolism via several key mechanisms, including (1) the reduction of oxidative stress during ethanol oxidation via eliminating oxygen, superoxide anions, and hydroxyethyl radicals (Wang et al., ; Wu et al., ); (2) activating hepatic ADH and ALDH, which can reduce the serum alcohol concentration (Yamaguchi et al., ; Yu et al., ); and (3) modulating the NADH/NAD + ratio to change the redox system and slowing the absorption rate of alcohol to prevent a dramatic increase in serum alcohol level (Yamaguchi et al., ).…”

The Effects of Corn Peptide Ingestion on Facilitating Alcohol Metabolism in Healthy Men

“…It is likely that the effect of CP ingestion on facilitating alcohol metabolism may be due not only to the potential supply ofNAD + by the metabolism of alanine, leucine, and proline from CP, but also to the delay of release of ethanol from the stomach or malabsorption of ethanol in the gastrointestinal tract. 2) Concerning alcohol metabolism in animals, the ability to metabolize alcohol is affected by nutritional conditions and the rats fed with a low protein diet had poorer ability for alcohol metabolism due to the deficiency of amino acids, especially essential amino acids. 3 .…”

“…2 ) CP is an oligopeptide produced by proteolysis using alkaline protease from alkalophilic Bacillus A-7, which is the product of Nihon Shokuhin Kako Co., Ltd., Japan. It is likely that the effect of CP ingestion on facilitating alcohol metabolism may be due not only to the potential supply ofNAD + by the metabolism of alanine, leucine, and proline from CP, but also to the delay of release of ethanol from the stomach or malabsorption of ethanol in the gastrointestinal tract.…”