Stimulated salivary flow rate, pH and lactobacillus and yeast concentrations in medicated persons

Abstract

Parvinen T, Parvinen I, Larmas M: Stimulated salivary flow rate, pH and lactobacillus and yeast concentrations in medicated persons. Scand J Dent Res 1984; 92: 524-32.Abstract -Flow rate, pH and hu tobacillus and yeast counts of paraflin-stiniulated whole saliva were analyzed in an adult population of 463 medicated persons. Ofthe very large number of drugs only a few groups were found to decrease salivation to such an extent that they can be considered to cause dental harm. Persons using neuroleptics, tricyclic antidepressants or antihypertensives were nevertheless found to produce stimulated saliva at rates significantly lower than unmedicated persons. Age had no influence on the flow rate, but postmcnopausal age seems to predispose medicated women to a decrease in salivary How. Higher microbial counts were found in the medicated men.

Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages

“…Recent studies have also demonstrated that both stimulated and unstimulated salivary flow rates do not decrease in healthy elderly subjects. 9,[21][22][23] There was a statistical difference in the mean flow rate between the young and elderly groups in the high buffering capacity group, which may have been influenced by the very high flow rate obtained for the young group. However, there was no statistical difference in the mean flow rate between the middle-aged and elderly groups.…”

The pH change after HCl titration into resting and stimulated saliva for a buffering capacity test

“…21,22 However, recent studies have also demonstrated that both stimulated and unstimulated parotid salivary flow rates are not reduced in healthy elderly subjects. 23,24 In the present study, 11 out of 80 patients were over 60 years of age. Only three out of 11 patients taking prescribed medication showed a low buffering capacity for both resting and stimulated saliva.…”

Association of blood pressure and antihypertensive drugs with diurnal alpha-amylase activity

“…More recent studies demonstrated an attenuating effect of propanolol on stress-induced sAA changes (Van Stegeren et al, 2006) and found that administering yohimbine hydrochloride, an alpha-2-adrenergic receptor antagonist that activates the SNS, increases sAA activity (Ehlert et al, 2006). Given these observations, adrenergic agonists and antagonists may change sAA activity due to their impact on adrenoceptor mediated protein secretion (Garrett, 1987;Proctor and Shori, 1996;Busch and Borda, 2000) and salivary flow rate (Parvinen et al, 1984). Up to date, only two studies investigated the effects of regular AD consumption on basal sAA activity and showed a diminishing effect on sAA activity (Nederfors et al, 1994;Nederfors and Dahlöf, 1996).…”