Association of blood pressure and antihypertensive drugs with diurnal alpha-amylase activity

Strahler, Jana; Kirschbaum, Clemens; Rohleder, Nicolas

doi:10.1016/j.ijpsycho.2011.04.002

Cited by 11 publications

(16 citation statements)

References 45 publications

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“…In our study, lower blood pressure values correlated signi cantly with higher sAA awakening levels, opposing results found by J. Strahler et al [15] who found a trend towards higher diurnal output of sAA in hypertensive individuals and in individuals taking antihypertensive drugs this di erence was smaller. Decisive di erences between the two studies could have been rst the age of the participants, ours being considerably older, second the prevalence of HF in our own study group and the consequently intake of HF medications, including BBs.…”

Section: Discussioncontrasting

confidence: 99%

“…is work was triggered by the question if sAA activity, a promising non-invasive biomarker of the SNS [6][7][8][9][10][11][12][13][14][15] has the potential of being a biomarker in HF. HF and other cardiovascular diseases are o en associated with SNS overactivity and norepinephrine, another biomarker of sympathetic overactivity, has shown to be an important predictor of all-cause mortality and rst morbid events in HF [16].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is a strong tendency of morning values being higher in patients, with the measurement taken 30 min a er awakening showing the clearest distinction. BBs, which are taken by all patients are known to decrease sAA levels [14,15]. Unfortunately, the time of intake of medication was not recorded, however most likely did this happen a er the second morning-measurement, 30 min a er awakening, and the fact that stronger di erences between control and patients were seen in the morning was possibly due to decreased drug levels in blood in the morning just before medication intake.…”

Section: Discussionmentioning

confidence: 99%

“…However it could be shown that sAA activity is increased during stress, both physical and psychological [6,7,11], that it correlates with norepinephrine release [12] and that β-adrenoceptor antagonists (BBs) have a reducing e ect on sAA activity levels [13,14]. Recent studies have also shown a tendency of higher total output of sAA in hypertensive humans, compared to normotensive ones [15].…”

Section: Introductionmentioning

confidence: 99%

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Salivary Alpha-Amylase Activity, a New Biomarker in Heart Failure?

Suska

Alehagen²,

Lundström³

et al. 2012

J Clin Exp Cardiolog

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Abstractsystem. Autonomic imbalance is associated to several diseases, one of which is heart failure, and the aim of the Methods: In this pilot study, 48 elderly men (range 59-89 years), 24 patients with established chronic heart failure in NYHA class I to III, and 24 controls were included. In all participants, saliva was collected for three consecutive days at three time points (at awakening, 30 minutes later and in the late afternoon), and blood was sampled for analysis of NT-proBNP. Results:levels with arterial blood pressure.to be a negative correlation with blood pressure. Conclusions:Our data supports the idea that sAA activity has the potential as a non-invasive index of adrenergic sAA activity levels, we expect a greater potential for monitoring its changes over time, which could prove a valuable surrogate biomarker for cardiovascular diseases, including heart failure.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary Alpha-Amylase Activity, a New Biomarker in Heart Failure?

Suska

Alehagen²,

Lundström³

et al. 2012

J Clin Exp Cardiolog

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“…54 The underlying neurohormonal links between yoga and its influence on BP have not been fully delineated. As stated earlier, salivary a-amylase is a biomarker of SNS activation, 55 while cortisol is a marker for HPA axis regulation. 46 Reduction in these markers infers a shift in SNS and HPA axis regulation toward parasympathetic dominance that relates to decrease BP.…”

Section: Salivary A-amylasementioning

confidence: 89%

Effects of Hatha Yoga on Blood Pressure, Salivary α-Amylase, and Cortisol Function Among Normotensive and Prehypertensive Youth

Sieverdes

Mueller²,

Gregoski³

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objective: Evidence is accumulating, predominantly among clinical trials in adults, that yoga improves blood pressure (BP) control, with downregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS) projected as underlying mechanisms. This pilot study assessed whether Hatha yoga has the potential to reduce BP among youth and whether dampening of the SNS and/or HPA activity is a likely pathway of change. Design: Thirty-one seventh graders were randomly assigned to a Hatha yoga program (HYP) or attention control (AC) music or art class. Baseline and 3-month evaluations included resting BP; overnight urine samples; and saliva collected at bedtime, upon awakening, and at 30 and 60 minutes after awakening for a-amylase and cortisol assays. Results: Twenty-eight (14 in the HYP group and 14 in the AC group) students were assessed both before and after the intervention. BP changes from pre-to post-intervention were -3.0/ -2.0 mmHg for the HYP group and -0.07/ -0.79 mmHg for the AC group (p = 0.30 and 0.57, respectively). Changes in systolic BP (SBP)/diastolic BP (DBP) for the prehypertensive (75th-94th percentiles for SBP) subgroup analyses were -10.75/ -8.25 mmHg for the HYP group (n = 4) versus 1.8/1.0 mmHg for the AC group (n = 5) ( p for SBP = 0.02; p for DBP = 0.09). Although no statistically significant group differences were observed with changes in SNS or HPA awakening curves (area under curve for a-amylase and cortisol, respectively), a small to moderate effect size was seen favoring a reduction of a-amylase activation for the HYP group (Cohen d = 0.34; prehypertensive d = 0.20). Conclusions: A school-based Hatha yoga program demonstrated potential to decrease resting BP, particularly among prehypertensive youth. Reduced SNS drive may be an underlying neurohormonal pathway beneficially affected by the program. A large-scale efficacy/effectiveness randomized clinical trial is warranted.

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