Stiff micelle-crosslinked hyaluronate hydrogels with low swelling for potential cartilage repair

Abstract

Pluronic F127 diacrylate (F127DA) micelle-crosslinked methacrylated hyaluronic acid (MeHA) hydrogel with low-swelling and strong compressive properties was successfully synthesized for the regeneration of cartilages in vivo.

One‐Pot Synthesis of a Copolymer Micelle Crosslinked Binder with Multiple Lithium‐Ion Diffusion Pathways for Lithium–Sulfur Batteries

“…Furthermore, the thin and uniform distribution of solid Li 2 S 2 and Li 2 Sinalayer on the surfaceo ft he FNA electrode hardly influences the Li-iond iffusion, resultingi nl ow polarization in the electrode. [36] The SEM image at low magnification of the electrode with PVDF after 100 cycles shows that the surface of the PVDF electrode has some large cracks ( Figure S9 ai nt he Supporting Information), whereas no large cracks are observed on the surface of the electrode with FNA ( Figure S9 bint he Supporting Information). The large number of cracks on the PVDF electrode originate from the crystal structure of PVDF,w hich can not releaset he stress during the lithiation/delithiation process.…”

“…In contrast, for the FNA electrode after the 100th cycle, the active materials are still dispersed uniformly in the electrode, maintaining the continuous conductive network and excellent conductivity, which is in accord with the EIS measurements (Figure b). Furthermore, the thin and uniform distribution of solid Li 2 S 2 and Li 2 S in a layer on the surface of the FNA electrode hardly influences the Li‐ion diffusion, resulting in low polarization in the electrode . The SEM image at low magnification of the electrode with PVDF after 100 cycles shows that the surface of the PVDF electrode has some large cracks (Figure S9 a in the Supporting Information), whereas no large cracks are observed on the surface of the electrode with FNA (Figure S9 b in the Supporting Information).…”

Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent

“…To address the above issues, we recently developed a methacrylated hyaluronic acid (MeHA) hydrogel crosslinked by diacrylated PEO 99 -PPO 65 -PEO 99 triblock copolymer (F127DA) micelles with a diameter of 10-20 nm. 6,7 It displays outstanding strength, toughness and long-term network maintaining, which is attributed to the efficient energy dissipation through the hydrophobic association of PPO blocks in the core of micelles.…”

Dual-enzymatically crosslinked and injectable hyaluronic acid hydrogels for potential application in tissue engineering

“…4,9 Along with its favourable properties such as inherent biocompatibility, water adsorption ability and biodegradability, mediated by natural hyaluronidases in the body, HA-based hydrogel has been considered as one of the most suitable biomaterials for a variety of tissue engineering applications. [10][11][12][13][14] Despite these outstanding features, its further applicability is still hindered by some shortcomings, such as, low mechanical strength and quick degradation kinetics.…”