Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent

Abstract

Introducing macromolecular micelles into the biocompatible hyaluronate acid (HA) hydrogel is a promising strategy to improve its mechanical properties for biomedical applications. However, it is still unclear whether the solvent...

Advances in modified hyaluronic acid-based hydrogels for skin wound healing

“…29 The rational design of functionalization materials and crosslinking methods is important for obtaining hydrogels that mimic the natural ECM and exert desired biological functions. 64,65,79,80 Therefore, the disclosure of chemical modifications for the functionalization of HA in the manufacturing of HA-based hydrogels in recent years was organized, and various crosslinking techniques for the formation of multifunctional biocompatible HA-based hydrogels were summarized (Table 1), including physical and chemical crosslinking strategies.…”

Deep Eutectic Solvent‐Based Ultra‐Stretchable, Anti‐Freezing, and Ambient‐Stable Supramolecular Ionogel for Wearable Sensor

“…The other is that when the gel is placed at room temperature, the hydrogel will lose water, resulting in poor solvent retention of the gel, which affects the performance of the gel. [11][12][13][14][15] These two factors seriously hinder its practical application in real life. Therefore, how to design and prepare an anti-freezing gel with the properties of traditional hydrogels and environmental stability is very important.…”

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

“…Solvent concentration-responsive swelling Swelling measurements were performed in dimethyl sulfoxide (DMSO)-water mixtures at 25 • C and are presented in Figure 12. Hydrophobic isopropyl groups on the network chains are responsible for reentrant phase transitions of hydrogels in DMSO-water mixtures [39,40]. In DMSO-water mixtures, hydrophobic isopropyl groups in the hydrogel reduce the interaction between water and hydrogel, leading to a strong attraction of water molecules by DMSO.…”

“…Table 8 presents the values of φ, ω, RP, and σ with standard error (SE) found from Equation (6), and RPS (swelling in RP value). Hydrophobic isopropyl groups on the network chains are responsible for reentrant phase transitions of hydrogels in DMSO-water mixtures [39,40]. In DMSO-water mixtures, hydrophobic isopropyl groups in the hydrogel reduce the interaction between water and hydrogel, leading to a strong attraction of water molecules by DMSO.…”