Steroid therapy reduces mesangial matrix accumulation in advanced IgA nephropathy

Kuriki, Minoru; Asahi, Koichi; Asano, Kenichiro; Sakurai, Kazuo; Eiro, Masaaki; Suzuki, Hodaka; Watanabe, Kazuo; Katoh, Tetsuo; Watanabe, Tsuyoshi

doi:10.1093/ndt/gfg135

Cited by 20 publications

(7 citation statements)

References 11 publications

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“…Repeat biopsies in the steroid-treated group showed a decreased matrix crescent formation and time until doubling of serum creatinine was lengthened. In 16 adult patients with advanced IgA nephropathy, Kuriki et al [67] administered a loading dose of methylprednisolone followed by 10–15 mg prednisolone per day. The urinary protein before treatment was 1.6 ± 1.7 g/day and dropped to 0.4 ± 0.2 g/day after therapy (p < 0.005).…”

Section: Clinical Studies In Prevention Of Progression In Iga Nephropmentioning

confidence: 99%

Modulating the Progression in IgA Nephropathy

Chan

Trachtman

2006

Nephron Clin Pract

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IgA nephropathy affects almost 1% of the population and yet the diagnosis is often missed. This significant kidney disease is often progressive with 25% of the patients going on to end-stage kidney disease over the course of 25 years. This minireview describes the clinical presentations in children and young adults. Therapeutic options are discussed including angiotensin-converting enzyme blockade, steroids, cytotoxics, tonsillectomy, fish oil, vitamin E, singly or in combination, in order to modulate the rate of progression.

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Section: Clinical Studies In Prevention Of Progression In Iga Nephropmentioning

confidence: 99%

Modulating the Progression in IgA Nephropathy

Chan

Trachtman

2006

Nephron Clin Pract

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“…The morphometric analysis was performed with a system composed of a microscope (BX50, Olympus, Tokyo, Japan) attached to a color CCD camera (HC-2500, Fujix, Tokyo, Japan) and a computer (FMV 6400 TX2, Fujitsu, Tokyo, Japan), using image analysis software Winroof v3.31 (Mitani, Tokyo, Japan). Imaging analysis consisted of the following steps [15]: (1) capturing glomeruli on the PAS preparation at a magnification of ×200; (2) tracing the outline of the glomeruli to obtain the total glomerular area, and (3) selecting the PAS-positive area manually with the mouse pointer. Finally, the mesangial matrix index (MMI) was calculated from the ratio of the PAS-positive area to the glomerular area.…”

Section: Methodsmentioning

confidence: 99%

Dietary Perilla Seed Oil Supplement Increases Plasma Omega-3 Polyunsaturated Fatty Acids and Ameliorates Immunoglobulin A Nephropathy in High Immunoglobulin A Strain of ddY Mice

Sakurai

Asahi

Kanesaki

et al. 2011

Nephron Exp Nephrol

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Background/Aims: The beneficial effects of omega-3 polyunsaturated fatty acids (n–3 PUFA) in the treatment of immunoglobulin A nephropathy (IgAN) have been reported. Perilla frutescens (Linn.) Britton var. frutescens is grown in Eastern Asia and its seed (perilla seed) is rich in α-linolenic acid, an n–3 PUFA. We investigated the antinephritic effects of perilla seed oil in a mouse model of IgAN. Methods: Ten-week-old high IgA ddY mice were fed diets containing either perilla seed oil (PS group) or corn oil (C group, control). After 20 weeks, we compared body weight, blood pressure, serum creatinine levels, IgA levels, fatty acid composition, urinary protein excretion, mesangial matrix expansion, and glomerular transforming growth factor-β₁ mRNA expression between groups. Results: Serum n–3 PUFA levels were higher in the PS group than the C group (p < 0.001). Blood urea nitrogen levels were lower (p = 0.0246) and urinary protein excretion was reduced (p = 0.0198) in the PS group. Mesangial matrix expansion (p = 0.0063) and glomerular transforming growth factor-β₁ mRNA expression (p = 0.0291) were suppressed in the PS group. No significant differences between groups were found in body weight, blood pressure, serum IgA, and creatinine levels. Conclusions: Dietary perilla seed oil supplement could suppress the progression of IgAN.

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“…L'examen de biopsies ré nales de 16 patients avant et aprè s 12 mois d'une corticothé rapie à dose modé ré e a montré une ré duction de l'accumulation de matrice mé sangiale [129].…”

Section: Corticoïdesunclassified