Modulating the Progression in IgA Nephropathy

Chan, James C.M.; Trachtman, Howard

doi:10.1159/000093672

Cited by 15 publications

(19 citation statements)

References 137 publications

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“…The peak incidence of IgAN in children occurs between 9-10 years of age. 2 In the present study mean age of disease presentation was 10 ± 3.5 years, which is similar to above study. IgA nephropathy is more common in males than female 2 but here male to female ratio is 1:2.…”

Section: Resultssupporting

confidence: 91%

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Clinical Spectrum and Outcome of Childhood IgA Nephropathy - A Single Centre Experience

Rumana¹,

Iyengar

Vasudevan

2015

Northern Int. Med. Coll. J.

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Section: Resultssupporting

confidence: 91%

“…1,2 The clinical presentations of IgA nephropathy varies across the spectrum of initial renal menifestations, ranging from gross hematuria to acute nephritic syndrome 3 . Sometimes some patients also manifests with End stage renal disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical Spectrum and Outcome of Childhood IgA Nephropathy - A Single Centre Experience

Rumana¹,

Iyengar

Vasudevan

2015

Northern Int. Med. Coll. J.

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“…IgA nephropathy (IgAN) is the most common primary glomerulonephritis in children and adolescents worldwide [1,2]. The disease was described as a new clinical entity in 1968 [2].…”

Section: Introductionmentioning

confidence: 99%

“…The disease was described as a new clinical entity in 1968 [2]. Kidney biopsy is essential for diagnoses and shows a markedly expanded mesangium filled with IgA.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Concomitant Nephrotic IgA Nephropathy and Minimal Change Disease in Children

Shen

Mao

et al. 2015

Nephron

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Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in children and adolescents worldwide. Meanwhile, minimal change disease (MCD) is the most common cause of nephrotic syndrome in children. Recently, several case reports have revealed that IgAN can be complicated by MCD in adults. Here, we report our experience concerning the features of such patients in pediatrics. Methods: The clinical manifestations and pathological features of 197 children who presented with IgAN from December 2007 to November 2013 were analyzed retrospectively based on the criteria for nephrotic syndrome and MCD. Results: Among the 197 children diagnosed with primary IgAN, 25 (12.7%) patients presented with nephrotic syndrome, and 7 patients (2.8%) presented with MCD-like pathological features and nephrotic syndrome simultaneously. The cohort of 7 patients included 5 boys, and the median age was 8.9. All of the patients who were diagnosed with primary nephrotic syndrome were treated initially with corticosteroids. Except for 1 patient with steroid resistance who was lost to follow-up, the other 6 cases presented were steroid sensitive and remained in complete remission for the last follow-up, with median and mean follow-up durations of 30.5 and 34.5 months, respectively (range 10-65 months). Conclusions: This study revealed that IgAN and MCD may also coexist in children. Moreover, most of these patients who presented with nephrotic syndrome responded well to steroids and had a favorable prognosis. Large-scale studies are required, and careful attention should be paid to such complicated cases.

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“…Medications may be added or changed postdiagnosis. 1,9 Some researchers [13][14][15] have examined the efficacy of fish oils and increased vitamin E intake to help control symptoms of IgA nephropathy, especially in the early stages or with unconfirmed test results. Cardiovascular complications are more common in patients who are smokers or who have hypertension.…”

mentioning

confidence: 99%

Autoimmune Dysfunction and Subsequent Renal Insufficiency in a Collegiate Female Athlete: A Case Report

Leone

Kern

Williamson

et al. 2010

Journal of Athletic Training

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Objective: To present the case of a female collegiate basketball player who was diagnosed with Wegener granulomatosis of the eyes and immunoglobulin A (IgA) nephropathy. Background: A 19-year-old female collegiate basketball player presented to a rheumatologist, urologist, and nephrologist with severe eye pain and was diagnosed with Wegener granulomatosis and IgA nephropathy. At age 20, during routine follow-up testing, urine protein levels were found to be 3 times normal values (0–8 mg/dL), prompting the need for a kidney biopsy, which showed IgA nephropathy, another autoimmune disorder. Differential Diagnosis: Sinus infection, scleritis, lymphomatoid granulomatosis, Churg-Strauss syndrome, lupus erythematosus, general granulomatosis. Treatment: Initial assessment revealed signs and symptoms, particularly in the patient's eyes, consistent with a sinus infection and scleritis. Her corneas were examined by a specialist, who prescribed various medications, including prednisone, for the relief of symptoms. When the dosage of prednisone was reduced, symptoms returned. Further tests revealed the presence of anti-neutrophil cytoplasmic antibody, a protein associated with Wegener granulomatosis, which helped confirm the diagnosis. The following year, a routine urinalysis showed abnormal levels of protein in her urine. A kidney biopsy revealed that IgA nephropathy also was present. At the time of this case report, the athlete continues to be monitored by an ophthalmologist who specializes in Wegener granulomatosis, a rheumatologist, and a nephrologist. Uniqueness: This athlete presented with 2 rare autoimmune disorders at an early stage of life. The medications used to treat the disorders left the athlete fatigued on a daily basis. Additionally, she was placed on 3 immunosuppressant drugs, which increased her risk for further health complications, yet she was able to successfully compete in athletics at the collegiate level. No family history of renal disease or other autoimmune disorders was discovered, further adding to the complexity and uniqueness of this case. Conclusions: Autoimmune disorders, such as Wegener granulomatosis, can present with a variety of common signs and symptoms. As athletic trainers, we encounter a host of unusual signs and symptoms; however, in cases such as this, further investigation into the cause of the chief complaints can go a long way toward restoring or managing an athlete's health. Excellent communication among the sports medicine team helped this athlete manage her potentially life-threatening condition while allowing her to remain active in her sport.

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Modulating the Progression in IgA Nephropathy

Cited by 15 publications

References 137 publications

Clinical Spectrum and Outcome of Childhood IgA Nephropathy - A Single Centre Experience

Clinical Spectrum and Outcome of Childhood IgA Nephropathy - A Single Centre Experience

Clinical Characteristics of Concomitant Nephrotic IgA Nephropathy and Minimal Change Disease in Children

Autoimmune Dysfunction and Subsequent Renal Insufficiency in a Collegiate Female Athlete: A Case Report

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