Steroid-Induced Gastric Ulcer

GARB, ALLAN E.

doi:10.1001/archinte.1965.03870060097021

Cited by 19 publications

(2 citation statements)

References 4 publications

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“…The occurrence of gastric ulceration with or without perforation, coincident with administration of corticosteroids or ACTH has been documented (Freidberger et a1 ., 1958;Garb et al, 1965). This situation may have been the circumstance in our patient with dermatomyositis who presented with perforation of a previously undetected gastric carcinoma, shortly after a course of ACTH therapy.…”

Section: Discussionmentioning

confidence: 80%

Perforation in gastric malignancy

Cortese

Zahn

Cornell

1972

Journal of Surgical Oncology

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Perforation in gatric malignancy is a rare condition, occurring in only 20 patients at the New York Hospital‐Cornell Medical Center between 1932 and 1969. Two patients are reported in whom plication followed by gastrectomy produced a satisfactory result. Early diagnosis of gastric cancer can be achieved by gastrointestinal x‐rays, allowing for appropriate therapy prior to perforation. If perforation does occur, the edge of the perforation should be biopsied and diagnostic analysis carried out. If feasible, primary gastrectomy is considered the treatment of choice. Otherwise, plication soon followed by definitive gastrectomy is recommended.

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Section: Discussionmentioning

confidence: 80%

Perforation in gastric malignancy

Cortese

Zahn

Cornell

1972

Journal of Surgical Oncology

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“…Generally peptic ulcers in corticosteroid-treated patients tend to show a predominance of gastric (usually antral) over duodenal ulcers, the reverse of the control population [25,34]. However, the description of the individual ulcer ranges from large and deep [34], to shallow [25], to indistinguishable from idiopathic ulcers [35]. There has been general agreement that peptic ulcers in steroid patients show less surrounding edema, spasm, and scarring, perhaps related to the anti-inflammatory effect of the corticosteroids [25,36,37].…”

Section: Corticosteromsmentioning

confidence: 99%

Drug-induced gastrointestinal disease

Hyson

Burrell

Toffler

1977

Gastrointest Radiol

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The gastrointestinal tract is a common target for adverse drug reactions. The resultant changes are often nonspecific (e.g., mucosal ulceration, intestinal infarction, motility disturbance) and in many cases no radiographically detectable lesion may occur. A comprehensive review of the reported drug-induced disorders of the digestive organs is herein presented and their radiographic manifestations are described.

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