Between 1932 and 1970, 75 patients with primary duodenal tumors have been observed at The New York Hospital–Cornell Medical Center, excluding tumors of the ampulla of Vater. The duodenal tumor in 32 of these patients was malignant. The signs and symptoms of duodenal malignancy will depend on the proximity to the papilla as well as the growth characteristics of the cancer. Upper gastrointestinal barium radiography is the most accurate current diagnostic tool. When feasible, pancreaticoduodenal resection of the cancer and regional node‐bearing area is considered the most effective modality in attempting cure. The crude 5‐year survival of 14 patients subjected to this procedure was 28%.
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