Stereotactic hypofractionated high-dose irradiation for stage I non-small cell lung carcinoma: Clinical outcomes in 273 cases of a Japanese multi-institutional study

Quality of Life After Stereotactic Radiotherapy for Stage I Non-Small-Cell Lung Cancer

“…Although the incidence of toxicity is not mentioned by Langendijk et al (15), the low incidence of toxicity after SRT may be the reason why symptom scores did not increase in our study. The risk of late toxicity is small (2-8%) after treating patients with SRT, as treatment volumes are generally small (4,12,16). On the other hand, the risk of toxicity after stereotactic irradiation of central tumors is not negligible (17) and may influence the patient's QoL.…”

“…Although surgery is the treatment of choice, many patients have tumors that are medically inoperable due to smoking-related comorbidity. For these patients, SRT is a good alternative treatment, achieving local tumor control rates above 90% (1-3) and 5-year overall survival rates of 47% (4). An equally important aim of any cancer treatment is to maintain or improve the patient's quality of life (QoL).…”

Estimation of Errors Associated With Use of Linear-Quadratic Formalism for Evaluation of Biologic Equivalence Between Single and Hypofractionated Radiation Doses: An In Vitro Study

“…Gammaknife stereotactic radiosurgery (SRS) usually provides single-fraction stereotactic irradiation, and frameless linear accelerator-based stereotactic irradiation and the cyberknife can offer, not only single-fraction SRS, but also fractionated stereotactic radiotherapy (SRT). Hypofractionated SRT has been increasingly used as an alternative to surgery for Stage I non-small-cell lung cancer (1)(2)(3). For malignant tumors containing hypoxic cells, SRT appears to be more efficient than single-fraction SRS because it takes advantage of the reoxygenation of hypoxic tumor cells during fractionation (4)(5)(6)(7).…”

“…It remains unclear whether the LQ formalism is applicable to radiotherapy with a few fractions. Nevertheless, many clinicians have used the LQ formalism with single or hypofractionated radiation schedules (1,(12)(13)(14), because no other model is adequate to compare the biologic effects of single and hypofractionated radiation doses. In the present study, therefore, we investigated the reliability of the LQ formalism and magnitude of errors associated with its use when comparing single and hypofractionated radiation doses using in vitro single cell lines and spheroids.…”

Dose–Volume Comparison of Proton Radiotherapy and Stereotactic Body Radiotherapy for Non-Small-Cell Lung Cancer

“…Moreover, stereotactic radiosurgery and stereotactic radiotherapy with hypofractionated high doses have been aggressively performed recently for brain metastasis of NSCLC. In addition, stereotactic hypofractionated irradiation with X-rays is currently used in an attempt to treat patients with early-stage NSCLC to achieve higher local control (4)(5)(6), and hypofractionated irradiation with proton beams is also used (7,8).…”