Dose–Volume Comparison of Proton Radiotherapy and Stereotactic Body Radiotherapy for Non-Small-Cell Lung Cancer

Kadoya, Noriyuki; Obata, Yasunori; Katō, Takahiro; Kagiya, Masaru; Nakamura, Tatsuya; Tomoda, Takuya; Takada, Akinori; Takayama, Kohei; Fuwa, Nobukazu

doi:10.1016/j.ijrobp.2010.05.016

Cited by 65 publications

(35 citation statements)

References 37 publications

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“…Carbon-ions show considerably lower lateral scattering though, which should result in even better OAR sparing than protons. Our results are in agreement with several in silico studies comparing SBRT and proton therapy for NSCLC [Roelofs et al, 2012, Kadoya et al, 2010, Register et al, 2010. Furthermore, a study made by Kadoya reached the same conclusion as our study, that patients with larger CTV and/or multiple CTVs would receive less dose from proton therapy [Kadoya et al, 2010].…”

Section: Rbe and Proton Therapysupporting

confidence: 93%

“…Our results are in agreement with several in silico studies comparing SBRT and proton therapy for NSCLC [Roelofs et al, 2012, Kadoya et al, 2010, Register et al, 2010. Furthermore, a study made by Kadoya reached the same conclusion as our study, that patients with larger CTV and/or multiple CTVs would receive less dose from proton therapy [Kadoya et al, 2010]. A recent phase II trial for patients with multiple sites of extracranial disease showed good results for photons [Iyengar et al, 2014], however, based on the findings of Kadoya et al and our study, proton and/or carbon-ion therapy might result in even better outcome.…”

Section: Rbe and Proton Therapysupporting

confidence: 92%

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In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

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Stereotactic body image guided radiation therapy (SBRT) shows excellent results for the local control of early stage lung cancer. However, not all patients are eligible for SBRT, and advanced stage treatment is less successful and often associated with severe side effects. Scanned carbon ion therapy (PT) can deliver more conformal dose likely benefiting these patient groups.Therefore an in silico trial was conducted on early and advanced stage patients to identify potential advantages of PT. The patients were treated with SBRT at Champalimaud Center for the Unknown, Lisbon (Portugal). PT plans were simulated on 4DCTs, and rescanning was investigated for motion mitigation in 4D-dose calculations. A dedicated strategy for 4D intensity modulated particle therapy (IMPT) was developed and applied for advanced stage patients with multiple lesions. For clinically valid and reliable results the deformable image registrationnecessary for 4D-dose calculation -a quality assurance tool was developed and applied in the study.The results showed that target coverage was comparable in SBRT and PT, while PT delivered significantly lower doses to most critical structures, especially the heart, lungs, and esophagus.A highly complex case of advanced stage lung cancer could be treated in a single fraction of 24 Gy with PT, while SBRT could not deliver the full ablative dose treatment due to an excessive heart dose. The mean heart dose was reduced from 10 Gy to 0.8 Gy with PT for this specific patient.

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Section: Rbe and Proton Therapysupporting

confidence: 93%

Section: Rbe and Proton Therapysupporting

confidence: 92%

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

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“…Previous SBRT studies have suggested that the lung V5 (volume of lung receiving at least 5 Gy) is the most significant factor associated with radiation pneumonitis [22]. Regarding dose-volume comparison, proton therapy has been reported to deliver a lower mean dose to the lung and lower V5 values relative to SBRT [23, 24]. The advantages offered by PBRT include providing a precise dose localization and favorable dose-depth distribution using a small number of portals; these make it useful in limiting the area of normal tissue exposed to the low-dose region.…”

Section: Discussionmentioning

confidence: 99%

Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors

et al. 2014

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BackgroundA study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors.MethodsA total of 47 patients with 59 lesions who underwent PBRT for oligometastatic lung tumors between 2003 and 2011 were included in this study. Patient median age was 66 (range, 39–84) years. The primary tumor site was the colorectum in 11 patients (23.4%), lung in 10 patients (21.3%) and a variety of other sites in 26 patients (55.3%). Thirty-one patients (66%) received chemotherapy prior to PBRT. Thirty-three lesions were treated with 320-MeV carbon ions and 26 were treated with 150- or 210-Mev protons in 1–4 portals. A median total dose of 60 (range, 52.8–70.2) GyE was delivered at the isocenter in 8 (range, 4–26) fractions.ResultsThe median follow-up time was 17 months. The local control, overall survival and progression-free survival rates at 2 years were 79%, 54 and 27% respectively. PBRT-related toxicities were observed; six patients (13%) had grade 2 toxicity (including grade 2 radiation pneumonitis in 2) and six patients (13%) had grade 3 toxicity. Univariate analysis indicated that patients treated with a biologically equivalent dose of 10 (BED10) <110 GyE10, had a significantly higher local recurrence rate. Local control rates were relatively lower in the subsets of patients with the colorectum as the primary tumor site. No local progression was observed in metastases from colorectal cancer irradiated with a BED10 ≥ 110 GyE10. There was no difference in treatment results between proton and carbon ion therapy.ConclusionsPRBT is well tolerated and effective in the treatment of oligometastatic lung tumors. To further improve local control, high-dose PBRT with a BED10 ≥ 110 GyE10 may be promising. Further investigation of PBRT for lung oligometastases is warranted.

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“…Lung is classical Parallel Organ, therefore DV parameters method is often used to evaluate lung complication probability in radiotherapy. Usually, radiotherapist utilize dose-volume parameters, such as V 5 , V 20 , V 50 and mean lung dose (MLD), to evaluate lung injury in radiotherapy (13)(14)(15). But the method has a fatal defect, we will next demonstrate the defect.…”

Section: Technology In Cancer Research and Treatment 2014 June 30 Epubmentioning

confidence: 97%

A Quantitative LQ-based Model for Lung Injury in Radiotherapy

Wang

Bai

et al. 2014

Technol Cancer Res Treat

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Establishing a new bio-mathematical model, named quantitative LQ-based (qLQB) model, that can evaluate the radio-toxicity of lung. We assume that each Function Subunit (FSU) of lung is equal and representative in functional status. Based on the Linear-Quadratic model (LQ model), we had derived a model to calculate the ratio/percent (R/P) between damaged cell/FSU and entire cell/FSU of lung for radiation dose response. We can analyse radiation pneumonia probability (RPP) based on the R/P. Forty-five 3D plans from forty-five randomly selected lung cancer patients were generated using the ELEKTA precise 2.12 treatment planning system. The qLQB was tested against the widely used Lyman-Kutcher-Burman model (LKB model). There was no distinct statistical difference in analyzing RPP between using the qLQB model and the LKB model (p 5 0.412). The proposed qLQB model was found to be efficient and reliable for analyzing RPP.

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Dose–Volume Comparison of Proton Radiotherapy and Stereotactic Body Radiotherapy for Non-Small-Cell Lung Cancer

Cited by 65 publications

References 37 publications

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors

A Quantitative LQ-based Model for Lung Injury in Radiotherapy

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