Stereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reaction

Xu, Xiaoyan; Martinez, Pamela Robles; Madla, Christine M.; Joubert, Fanny; Goyanes, Álvaro; Basit, Abdul W.; Gaisford, Simon

doi:10.1016/j.addma.2020.101071

Cited by 131 publications

(109 citation statements)

References 47 publications

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“…In our study, tablets containing four different amounts of ATH suspended in PEGDA/PEG 400 mixture were successfully produced by the DLP printer. In the work by Xu et al (2020), PEGDA 575 and PEG 300 were used for production of the antihypertensive polyprintlet (irbesartan, atenolol, hydrochlorothiazide and amlodipine), where chemical reaction between a photopolymer and amlodipine reported [ 48 ]. Accordingly, different active substances could be dissolved or suspended in the PEGDA/PEGs mixtures, but it is important to investigate potential interactions between drugs and polymers.…”

Section: Resultsmentioning

confidence: 99%

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

et al. 2020

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Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.

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Section: Resultsmentioning

confidence: 99%

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

et al. 2020

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“…When compared to conventional manufacturing processes, this technology offers unique benefits for the manufacture of solid drug products, such as patient-tailored medicines [18] , retentive devices [19 , 20] , and customised drug release formulations [21 , 22] . Within the pharmaceutical field five main 3DP technologies are currently used; powder bed ink jet printing [23] , fused deposition modelling (FDM) [24] , selective laser sintering (SLS) [25] , stereolithography (SLA) [26] , and semi-solid extrusion (SSE) [27 , 28] .…”

Section: Introductionmentioning

confidence: 99%

3D printed tacrolimus suppositories for the treatment of ulcerative colitis

Seoane-Viaño

Ong

Luzardo-Álvarez

et al. 2021

Asian Journal of Pharmaceutical Sciences

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Ulcerative colitis is a global health problem, affecting millions of individuals worldwide. As an inflammatory condition localised in the large intestine, rectal delivery of immunosuppressive therapies such as tacrolimus is a promising strategy to maximise drug concentration at the site of action whilst minimising systemic side effects. Here, for the first time, self-supporting 3D-printed tacrolimus suppositories were prepared without the aid of moulds using a pharmaceutical semi-solid extrusion (SSE) 3D printer. The suppositories were printed vertically in three different sizes using combinations of two lipid pharmaceutical excipients (Gelucire 44/14 or Gelucire 48/16) and coconut oil. Although both suppository formulations had the appropriate viscosity characteristics for printing, the Gel 44 formulation required less energy and force for extrusion compared to the Gel 48 system. The Gel 44 disintegrated more rapidly but released tacrolimus more slowly than the Gel 48 suppositories. Although the tacrolimus release profiles were significantly different, both suppository systems released more than 80% drug within 120 min. DSC and XRD analysis was inconclusive in determining the solid-state properties of the drug in the suppositories. In summary, this article reports on the fabrication of 3D printed self-supporting suppositories to deliver personalised doses of a narrow therapeutic index drug, with potential benefits for patients with ulcerative colitis.

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“…Three-dimensional printing (3DP) is an innovative additive manufacturing technology that has come to the fore in the preparation of personalised dose printlets (3D printed tablets) [10][11][12][13][14]. 3D printing is an umbrella term that encompasses various technologies, many of which have already been evaluated in the pharmaceutical field [15][16][17][18], including powder bed inkjet printing, fused deposition modelling (FDM) [19][20][21][22][23][24][25][26][27], semi-solid extrusion (SSE) [28][29][30][31][32][33], selective laser sintering (SLS), direct powder extrusion (DPE) [34] and stereolithography (SLA) [15,[35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

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142

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The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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Stereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reaction

Abstract: Stereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reactionStereolithography (SLA) 3D printing of an antihypertensive polyprintlet: Case study of an unexpected photopolymer-drug reaction

Cited by 131 publications

References 47 publications

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

3D printed tacrolimus suppositories for the treatment of ulcerative colitis

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

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