Stem Cells: In Sickness and in Health

Bahmad, Hisham F.

doi:10.2174/22123946mta5entcf1

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under the long-term continuous inflammation stimulation, the alveolar bone can undergo pathological absorption and eventually lead to tooth loosening or even loss [1,2]. With the deepening of tissue-engineering research, the role of stem cells in bone tissue repair is increasingly prominent [3,4], but limitations such as limited in vitro amplification capacity, complex biological effects, and major biological functions which can be replaced by bioactive molecular combinations hinder the development and application [5,6].…”

Section: Introductionmentioning

confidence: 99%

miR-141-3p Targeted SIRT1 to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Zhou

Zhang

Wang

et al. 2023

Stem Cells International

View full text Add to dashboard Cite

Purpose. To explore the expression of miR-141-3p during the osteogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) and its regulatory effect. Methods. Differentiation of BMSCs was induced by dexamethasone. The mRNA expression of miR-141-3p, ALP, RUNX2, and OCN was measured using RT-qPCR. The protein expression was detected via western blot. The target of miR-141-3p was predicted through the TargetScan website and confirmed using luciferase reporter assay. Results. miR-141-3p expression declined during osteogenic differentiation. The relative ALP activities and the mRNA expression of ALP, RUNX2, and OCN were markedly reduced in the miR-141-3p mimic group while increased in the inhibitor group. Cell viability was suppressed in the miR-141-3p mimic group and promoted in the inhibitor group. SIRT1 was predicted to be a downstream gene of miR-141-3p, and this prediction was confirmed via the luciferase reporter assay. The results of the western blot assay demonstrated that SIRT1 expression was decreased in the miR-141-3p mimic group. SIRT1 reversed the inhibitory influence of miR-141-3p on the osteogenic differentiation ability of BMSCs. Conclusion. miR-141-3p targeted SIRT1 to inhibit osteogenic differentiation of BMSCs via the Wnt/β-catenin signaling pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

miR-141-3p Targeted SIRT1 to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Zhou

Zhang

Wang

et al. 2023

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…SCs are described as undifferentiated cells that are able to proliferate and transform into various types of mature cells that form different tissues and organs in the body ( Bahmad et al, 2021 ; Mahjoor et al, 2022 ). SCs are found in embryos and adult cells, and with each step of specialization, their differentiation potency decreases ( Zakrzewski et al, 2019 ; Mahjoor et al, 2021 ).…”

Section: Prefaced Of Stem Cells Function In Wound Repair Processmentioning

confidence: 99%

Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

Mahmoudvand

Rouzbahani²,

Razavi³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Diabetic foot ulcer (DFU) is considered the most catastrophic complication of diabetes mellitus (DM), leading to repeated hospitalizations, infection, gangrene, and finally amputation of the limb. In patients suffering from diabetes mellitus, the wound-healing process is impaired due to various factors such as endothelial dysfunction and synthesis of advanced glycation end-products, hence, conventional therapeutic interventions might not be effective. With increasing therapeutic applications of mesenchymal stem cells (MSCs) in recent years, their potential as a method for improving the wound-healing process has gained remarkable attention. In this field, mesenchymal stem cells exert their beneficial effects through immunomodulation, differentiation into the essential cells at the site of ulcers, and promoting angiogenesis, among others. In this article, we review cellular and molecular pathways through which mesenchymal stem cell therapy reinforces the healing process in non-healing Diabetic foot ulcers.

show abstract

“…Pluripotent stem cells, which are differentiated cells with stem cell-like properties, can adopt stem or progenitor cell-like phenotypes to adapt to microenvironmental changes, such as stress or injury [ 56 ]. They are especially prevalent in the liver and pancreas of adults.…”

Section: Model Of Cell Suspension Implantationmentioning

confidence: 99%

Infantile hemangioma models: is the needle in a haystack?

Kong

Wang

et al. 2023

J Transl Med

View full text Add to dashboard Cite

Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with distinct disease stages and durations. Despite the fact that the majority of IHs can regress spontaneously, a small percentage can cause disfigurement or even be fatal. The mechanisms underlying the development of IH have not been fully elucidated. Establishing stable and reliable IH models provides a standardized experimental platform for elucidating its pathogenesis, thereby facilitating the development of new drugs and the identification of effective treatments. Common IH models include the cell suspension implantation model, the viral gene transfer model, the tissue block transplantation model, and the most recent three-dimensional (3D) microtumor model. This article summarizes the research progress and clinical utility of various IH models, as well as the benefits and drawbacks of each. Researchers should select distinct IH models based on their individual research objectives to achieve their anticipated experimental objectives, thereby increasing the clinical relevance of their findings.

show abstract

Stem Cells: In Sickness and in Health

Cited by 7 publications

References 0 publications

miR-141-3p Targeted SIRT1 to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

miR-141-3p Targeted SIRT1 to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

Infantile hemangioma models: is the needle in a haystack?

Contact Info

Product

Resources

About