Stem Cells from Human Exfoliated Deciduous Teeth: Biology and Therapeutic Potential

Abstract

Stem cells isolated from human exfoliated deciduous teeth (SHEDs) are a type of mesenchymal stem cells (MSCs), widely investigated for regenerative treatment. They are isolated from dental pulp tissues remaining in physiologically shedding human deciduous teeth. Thus, SHEDs are easy to access and not required invasive procedure to obtain cells. SHEDs are multipotent mesenchymal stem cells; however, they possess distinct properties when compared to other MSCs. In this regard, SHEDs exhibit higher proliferative rate than bone marrow-derived MSCs and greater osteogenic differentiation potency than human dental pulp stem cells. This chapter reviews the isolation technique and basic characteristics of SHEDs. Moreover, the intracellular signalling involved in the stemness regulation and differentiation ability of SHEDs is discussed, particularly on fibroblast growth factor, Notch, and Wnt signalling. Finally, the potential regenerative therapeutic application of SHEDs is also described.

Células estromales mesenquimales de dientes temporales exfoliados: caracterización e intereses terapéuticos. Revisión sistemática

“…[1][2][3][4][5][6][7][8] Esta amplia variedad de tipos de células crea una plétora de oportunidades para el uso de SHED en los procesos de regeneración de tejidos. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Gráfico 5).…”

“…De acuerdo a los autores, como resultados se encontraron que la mayoría de ellos ha realizado estudios en dientes temporales, extrayendo la pulpa de estos, analizando la pulpa dental y apical [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. En cuanto al ligamento periodontal, solo algunos autores han realizado estudios in vitro, y muy pocos en tejido gingival.…”

Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth(Shed)- A Review

“…In addition to the fact that they play a large role in developing restorative medicine, their study reveals much information about the complex events that happen during human development 22 . SHED are heterogeneous populations of cells that have been isolated from exfoliated deciduous teeth 4 .…”

“…SHEDs have high proliferation potency and are multipotent mesenchymal stem cells. Taking these advantageous properties together, SHEDs are one of the candidate cell types for tissue regeneration study 4 . Tooth loss is a common condition that has been encountered in clinics, it affects mastication and also a series of physiological and psychological problems.…”

Stem Cells from Human Exfoliated Deciduous Teeth (SHED) – Turning Useless into Miracle: A Review Article

“…These cells have the ability of high proliferation potency and are multipotent mesenchymal stem cells. These cells not only differentiate into dental pulp-related cells, but also, other cell types such as osteoblasts, adipocytes, neuronal-like cells and endothelial cells [7]. Taking all these properties together, SHEDs are one of the candidate cell types for tissue regeneration study.…”