“…Our data indicate that this continuously perfused cell culture device prevents the buildup of metabolites. Similar with those reported by others (Webster and Bishopric, 1992;Webster et al, 1995Webster et al, , 1999, the new bioreactor used in this study is a feasible model system for the detection of the biological effects of cardiac preconditioning or reperfusion-injury that was explored previously by Murry et al (2006), Aoki et al (2004), Ball and Levine (2005), Schäffler and Büchler (2007), Roche et al (2007), Zhang et al (2006), Kinnaird et al (2004), Ohnishi et al (2007), and Bingong et al (2007).…”