Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Rahman, Md. Mominur; Islam, Md. Rezaul; Islam, Mohammad Touhidul; Harun-Or-Rashid, Md.; Islam, Md. Rakibul; Abdullah, Sabirin; Uddin, Mohammad Borhan; Das, Sumit; Rahaman, Md. Saidur; Ahmed, Mohiuddin; Alhumaydhi, Fahad A.; Emran, Talha Bin; Mohamed, Amany Abdel-Rahman; Faruque, Mohammad Rashed Iqbal; Khandaker, Mayeen Uddin; Mostafa‐Hedeab, Gomaa

doi:10.3390/biology11010147

Cited by 41 publications

(21 citation statements)

References 340 publications

(294 reference statements)

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“…Pharmacological evaluation of Ganoderma sp. has demonstrated its antibacterial, anti-HIV, anti-inflammatory, anti-proliferative, anti-diabetic, anticancer, hypocholesterolemic, and hepato-protective potential ( Sudheer et al, 2019 ; Mominur Rahman et al, 2021 ; Rahman et al, 2022 ). These mushrooms have also been proven to be helpful in the synthesis of NPs, particularly AgNPs.…”

Section: Green Synthesis Of Nanoparticlesmentioning

confidence: 99%

Green Metallic Nanoparticles: Biosynthesis to Applications

Chopra

Bibi

Singh

et al. 2022

Front. Bioeng. Biotechnol.

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Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.

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Section: Green Synthesis Of Nanoparticlesmentioning

confidence: 99%

Green Metallic Nanoparticles: Biosynthesis to Applications

Chopra

Bibi

Singh

et al. 2022

Front. Bioeng. Biotechnol.

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show abstract

“…GIT issues such diarrhea and colitis have also been documented in 30-40% of those who have been given anti-CTLA-4 antibodies [73]. Some of the less prevalent adverse effects, such as endocrine, nephritis, pancreatitis, and neurological diseases, should not be overlooked [59,[87][88][89][90][91].…”

Section: Diversitymentioning

confidence: 99%

“…Dermatological side effects are most common during the first two weeks after starting an immune checkpoint inhibitor medication. Around six weeks after initiating medication, GIT side effects are common [88,89]. Hepatitis can emerge anywhere from 1-49 weeks after the beginning of treatment, with a median of five weeks [90].…”

Section: Hysteresismentioning

confidence: 99%

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

et al. 2022

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Immunotherapy, which stimulates the body’s immune system, has received a considerable amount of press in recent years because of its powerful benefits. Cancer immunotherapy has shown long-term results in patients with advanced disease that are not seen with traditional chemotherapy. Immune checkpoint inhibitors, cytokines like interleukin 2 (IL-2) and interferon-alpha (IFN), and the cancer vaccine sipuleucel-T have all been licensed and approved by the FDA for the treatment of various cancers. These immunotherapy treatments boost anticancer responses by stimulating the immune system. As a result, they have the potential to cause serious, even fatal, inflammatory and immune-related side effects in one or more organs. Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell therapy are two immunotherapy treatments that are increasingly being used to treat cancer. Following their widespread usage in the clinic, a wave of immune-related adverse events (irAEs) impacting virtually every system has raised concerns about their unpredictability and randomness. Despite the fact that the majority of adverse effects are minimal and should be addressed with prudence, the risk of life-threatening complications exists. Although most adverse events are small and should be treated with caution, the risk of life-threatening toxicities should not be underestimated, especially given the subtle and unusual indications that make early detection even more difficult. Treatment for these issues is difficult and necessitates a multidisciplinary approach involving not only oncologists but also other internal medicine doctors to guarantee quick diagnosis and treatment. This study’s purpose is to give a fundamental overview of immunotherapy and cancer-related side effect management strategies.

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“…Glucose-lowering medicines incorporate insulin sensitizers (biguanides, metformin, and thiazolidinediones), insulin secretagogues (sulfonylureas, meglitinides), and glucosidase inhibitors (acarbose, miglitol) [ 18 ]. Most glucose-lowering treatments can cause genuine hypoglycemia, causing liver cell harm, lactic acidosis, irreversible neurological need, stomach-related pain, cerebral agony, and shakiness [ 19 , 20 , 21 ]. Therefore, researchers are attempting to foster more viable medications with fewer antagonistic impacts.…”

Section: Introductionmentioning

confidence: 99%

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

et al. 2022

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Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.

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Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Cited by 41 publications

References 340 publications

Green Metallic Nanoparticles: Biosynthesis to Applications

Green Metallic Nanoparticles: Biosynthesis to Applications

Emerging Management Approach for the Adverse Events of Immunotherapy of Cancer

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

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