Stem Cell Therapy for Cardiac Repair

Boyle, Andrew; Schulman, Steven P.; Hare, Joshua M.

doi:10.1161/circulationaha.105.590653

Cited by 156 publications

(54 citation statements)

References 130 publications

(43 reference statements)

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“…All rights reserved. stem cells have been explored, such as adult stem cells from the bone marrow, adipose tissue or peripheral blood [4][5][6]. Recent findings showed that adult human heart hosts a population of cardiac primitive CD117-positive cardiac progenitor cells (CPCs), which are responsible for physiological tissue homeostasis and regeneration.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane-based scaffolds for myocardial tissue engineering

et al. 2014

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Bi-layered scaffolds with a 0°/90° lay-down pattern were prepared by melt-extrusion additive manufacturing (AM) using a poly(ester urethane) (PU) synthesized from poly(ε-caprolactone) diol, 1,4-butandiisocyanate and l -lysine ethyl ester dihydrochloride chain extender. Rheological analysis and differential scanning calorimetry of the starting material showed that compression moulded PU films were in the molten state at a higher temperature than 155°C. The AM processing temperature was set at 155°C after verifying the absence of PU thermal degradation phenomena by isothermal thermogravimetry analysis and rheological characterization performed at 165°C. Scaffolds highly reproduced computer-aided design geometry and showed an elastomeric-like behaviour which is promising for applications in myocardial regeneration. PU scaffolds supported the adhesion and spreading of human cardiac progenitor cells (CPCs), whereas they did not stimulate CPC proliferation after 1–14 days culture time. In the future, scaffold surface functionalization with bioactive peptides/proteins will be performed to specifically guide CPC behaviour.

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Section: Introductionmentioning

confidence: 99%

Polyurethane-based scaffolds for myocardial tissue engineering

et al. 2014

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“…In particular, the question of whether transplanted cells regenerate new myocardium (either through differentiation or cell-cell signaling to endogenous precursor cells) to replace those lost to MI (9,10) remains unanswered. Additionally, the use of different cell populations and varying clinical protocols and their application in diverse patient groups has hampered any effort to compare outcomes using the various cell types with one another (11).…”

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confidence: 99%

Multimodality Noninvasive Imaging Demonstrates In Vivo Cardiac Regeneration After Mesenchymal Stem Cell Therapy

Amado

Schuleri

Saliaris

et al. 2006

Journal of the American College of Cardiology

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149

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With serially obtained MRI and MDCT, we demonstrate in vivo reappearance of myocardial tissue in the MI zone accompanied by time-dependent restoration of contractile function. These data are consistent with a regenerative process, highlight the value of noninvasive multimodality imaging to assess the structural and functional basis for myocardial regenerative strategies, and have potential clinical applications.

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“…Увеличение числа пациентов с обширными об-структивными изменениями в коронарных артери-ях, не поддающимися традиционным методам лече-ния, привело к активному изучению возможности использования генных и клеточных технологий для терапевтического ангиогенеза в кардиоваскулярной патологии [225,226]. Доказано, что трансплантация BMMNCs приводит к значительным клиническим улучшениям у пациентов с острым инфарктом мио-карда, а также при хронической ишемической бо-лезни сердца, не поддающейся классическим мето-дам лечения [227][228][229][230].…”

Section: костный мозгunclassified

Therapeutic Angiogenesis by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects

Bulgin¹,

Андреева

2015

RJTAO

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Angiogenesis is the process of new capillary formation by migration and proliferation of differentiated endothelial cells from pre-existing microvascular network. A number of angiogenic molecules and cell populations are involved in this complex of new vessel formation cascades resulting in the determination and organization of new tridimensional vascular network. The goal of therapeutic angiogenesis is to stimulate angiogenesis to improve perfusion, to deliver survival factors to sites of tissue repair, to mobilize regenerative stem cell populations, andultimately to restore form and function to the tissue. Growth factors and bone marrow as a source of bone marrow mononuclear cells represent a very interesting research fi eld for the realization of therapeutic angiogenesis in ischemic tissues. They provide a potential key component in the healing processes of ischemic injured tissues.

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Stem Cell Therapy for Cardiac Repair

Cited by 156 publications

References 130 publications

Polyurethane-based scaffolds for myocardial tissue engineering

Polyurethane-based scaffolds for myocardial tissue engineering

Multimodality Noninvasive Imaging Demonstrates In Vivo Cardiac Regeneration After Mesenchymal Stem Cell Therapy

Therapeutic Angiogenesis by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects

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