Therapeutic Angiogenesis by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects

Bulgin, Dmitry; Андреева, О. В.

doi:10.15825/1995-1191-2015-3-89-111

Cited by 2 publications

(1 citation statement)

References 172 publications

(117 reference statements)

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“…в XXI веке аутотрансплантация клеток костного мозга стала все чаще применяться для коррекции ишемических расстройств в различных органах и в первую очередь для лечения пациентов, страдающих ишемической болезнью сердца, а также при кинк [45].…”

Section: клеточные технологии в лечении критической ишемии нижних конечностейunclassified

Potential and Perspectives of Indirect Revascularization in Treatment of Lower Limbs Critical Ischemia

Yaroshkin¹,

Sushkou²,

Fralou³

2021

Novosti Khirurgii

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This review was undertaken by a literature search of the International scientific database PubMed and Cochrane library. The review highlights the issues and perspectives of indirect revascularization in the patients with lower limbs critical ischemia. The study revealedthat lower limbs critical ischemia remains the actual problem ofangiosurgery, despite of the widespread introduction of angioplasty and open vascular reconstruction. However, angioplasty and bypass surgery revascularization cannot be performed in some category of patients, so that the further improvement of indirect revascularization techniques has been of great interesttoresearchers. The severity of the ischemic process is determined not only by the mechanical blood flow restriction but also by the angiogenic potential of the surrounding soft tissues, foremost muscular one. Therefore, in the case of technical irreparability of the main blood flow it remains possible to preserve the limb by creating new vascular networks in the muscular tissue. Revascularizing osteotrepanation of the lower limb bones is considered to be theoptimal variant to achieve this result. The discontent of clinical outcomes occurred due to the slow development of the angiogenic effect, which in critical ischemia is fraught with loss of a limb until the maximal angiogenesis is reached. In recent years, cell therapyhas become a very promising and advanced scientific research topic. So that its methods have been actively introduced into practice; they are easily combined with revascularizing osteotrepanation and are able significantly accelerate angiogenesis induced by surgical bone injury. In this regard, there is reason to believe that curative effect increases when revascularising osteotrepanation is combined with cell therapy, including the use of bone marrow aspirates.

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Section: клеточные технологии в лечении критической ишемии нижних конечностейunclassified

Potential and Perspectives of Indirect Revascularization in Treatment of Lower Limbs Critical Ischemia

Yaroshkin¹,

Sushkou²,

Fralou³

2021

Novosti Khirurgii

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One-year results of the treatment of critical lower limb ischemia with indirect revascularization methods

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Belikov

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et al. 2019

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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The OBJECTIVEwas to compare the efficiency of autologous bone marrow cell implantation and lumbar sympathectomy in the treatment of chronic critical lower limb ischemia.MATERIAL AND METHODS. The complex examination and treatment of 66 patients with critical lower limb ischemia, divided into 2 statistically homogeneous groups, was analyzed. The first group underwent sympathectomy, and the second – autologous bone marrow cell transplantation.RESULTS. After 1 year, in patients of the second group, compared with the first, the clinical status increased by 51.5 %, the number of amputations decreased by 3 %, the physical component of health increased by 7.9 %, the psychological component – by 17.7 %.CONCLUSION. The autologous bone marrow cell transplantation was pathogenetically substantiated and effective.

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Therapeutic Angiogenesis by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects

Cited by 2 publications

References 172 publications

Potential and Perspectives of Indirect Revascularization in Treatment of Lower Limbs Critical Ischemia

Potential and Perspectives of Indirect Revascularization in Treatment of Lower Limbs Critical Ischemia

One-year results of the treatment of critical lower limb ischemia with indirect revascularization methods

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