This paper is focused on the linearization of the radio frequency power amplifier of a professional digital handheld by means of an artificial neural network. The simplicity of the neural network that is used, together with the fact that a feedback path is unnecessary, make this solution ideal to reduce both the cost of a handheld and its hardware complexity, while fully maintaining its performance. A compensation system is also needed to keep the linearization characteristics of the neural network stable against frequency, temperature and voltage variations. The whole solution that comprises both the neural network and the compensation system has been implemented in the DSP of a real handheld and afterwards fully tested. It has proved to be satisfactory to meet the telecommunication standard requirements in all frequency, temperature and voltage ranges under consideration, while efficient to lower the computational cost of the handheld and to make its internal hardware simpler in comparison with other traditional linearization techniques. The results obtained demonstrate that a neural network can be used to linearize the power amplifiers that are used in transmitters of telecommunication equipment, leading to a significant reduction of both their hardware cost and complexity.