Status of vitamin D levels in hypothyroid patients and its associations with TSH, T3 and T4 in north Indian population of Meerut, a cross sectional study

Koch, Nirensingh; Kaur, Jaskiran; Mittal, Anju; Gupta, Akash; Kaur, Inder Pal; Agarwal, Shikha

doi:10.5958/2394-6377.2016.00057.5

Cited by 8 publications

(12 citation statements)

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“…Most of the participants as well as hypothyroid patients belonged to 30-50 years of age. This finding was also observed in different studies that the prevalence of hypothyroidism increases with age(9,17). Women suffer from hypothyroidism more than men worldwide(18).…”

supporting

confidence: 81%

“…Scatter diagram showing moderate positive correlation between serum FT4 and serum vitamin D.DISCUSSIONThe symptoms of hypothyroidism and serum vitamin D merges each other like unexplained tiredness, musculoskeletal pain, poor wound healing, hair loss, repeated respiratory tract infection, depression, bone loss(1,4). Few studies have been conducted in order to find any significant association between the levels of vitamin D and hypothyroidism and to determine whether vitamin D deficiency involves in the pathogenesis of hypothyroid-ism or rather a consequence of the disease and those studies yielded ambiguous and inconclusive results(9)(10)(11). Some researchers examined the prevalence of Vitamin D deficiency in different populations worldwide but this study was aimed to examine the association of Vitamin D level with hypothyroidism in Bangladeshi population.…”

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confidence: 99%

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Serum Vitamin D Status in Newly Diagnosed Hypothyroid Patients

Khan¹,

Sultana

Mou

et al. 2019

Bangladesh J. Nuclear Med.

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More than billion people worldwide are vitamin D deficient. It is recognized to have function in bone and muscle development by regulating calcium and phosphorus metabolism. Its role as an immune modulator has recently been discovered. Deficiency of vitamin D has been discovered to be associated with various cardiovascular, infectious, malignant, hypothyroidism and autoimmune thyroid diseases. Prevalence of hypothyroidism and hypovitaminosis D in Bangladesh is not known but supposed to be high because our neighbor country India has high prevalence. Vitamin D mediates its effect through binding to vitamin D receptor (VDR) and activation of VDR- responsive genes. VDR gene polymorphism was found to be associated with autoimmune thyroid diseases. On the other way hypothyroidism either decreases the metabolism of vitamin D or prevents to activate it. A total of 38 adult hypothyroid otherwise healthy patients and age, sex, BMI, socioeconomic status matched euthyroid adults were included in the study. The mean age in the hypothyroid group was 37.82 ± 7.95 years and in the euthyroid group was 34.84 ± 8.61 years. Male participants were14 and female participants were 24 in each group. The mean value of serum vitamin D of healthy group was 17.11 ± 5.62 ng/ml and in hypothyroid patients was 13.16 ± 4.29 ng/ml., Hypothyroid patients had significantly lower levels of serum Vitamin D3 as compared to controls (p =0.037,<0.05). Negative correlation was observed between serum TSH and serum vitamin D (r=-.119, p=.034), moderate positive correlation was observed between serum FT4 and serum vitamin D ((r=0.457, p=0.01, P<0.05). Bangladesh J. Nuclear Med. 22(1): 47-52, Jan 2019

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supporting

confidence: 81%

mentioning

confidence: 99%

Serum Vitamin D Status in Newly Diagnosed Hypothyroid Patients

Khan¹,

Sultana

Mou

et al. 2019

Bangladesh J. Nuclear Med.

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“…While many authors showed that serum vitamin D level decreases in several thyroid disorders [19,23], our data showed less statistically significant positive relation between serum vitamin D level and TSH when linear regression was done, ( r value is 0.279, R square = .078, beta regression coefficient = -.055 and p value <0.0005)…”

Section: Methodscontrasting

confidence: 83%

“…Many studies were conducted to find if there is an association between vitamin D deficiency and hypothyroid disorders, whether vitamin D involved in pathogenesis or even a sequalae of a thyroid illness [13,18,19].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study

ELAMAWY

Ameen

2021

Benha Medical Journal

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Background: the prevalence of subclinical hypothyroidism worldwide is commoner than the overt disease. Limited studies discussed the vitamin D levels in subclinical hypothyroid patients. Giving vitamin D supplements may prevent form developing overt hypothyroidism. In this cross-sectional case-control study, we described the differences in the vitamin D of adult Saudis with and without subclinical hypothyroid dysfunction. Methods:This is an observational single-center, retrospective, age, and sex matched, case-control study. A total of 60 subjects [41 healthy controls, 19 subclinical hypothyroid case] were included. 25(OH) vitamin D, TSH, free T4 and free T3 are measured in both groups. Results: Subjects with subclinical hypothyroid dysfunction had a significantly lower serum Vitamin D than controls (p value 0.016) although both groups fall below vitamin D sufficiency levels. Correlation is found between both vitamin D and TSH, p value 0.036. but it was found to be less statistically significant positive relation, r value is 0.279, (R square = .078, beta regression coefficient = -.055 and p value <0.0005) Conclusion: Patients with hypothyroid dysfunction showed much lower serum vitamin D compared to controls but it has not that big role in early hypothyroid disorders as shown in less significant relation.

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“…There are 7-95% females and 1-2% males across the world that has variable thyroid conditions. 15 In previous decades, Vitamin D3 deficiency was considered virtually non-existent in the Indian population as India lies in the tropical area. 16 But now a days various studies have revealed that 50-90% of the Indian population is deficient in Vitamin D3 due to inadequate dietary intake of Calcium.…”

Section: Discussionmentioning

confidence: 99%