Introduction: Diabetes is chronic disease which is characterised by defect in insulin secretion and insulin action leading to hyperglycaemia. Aim: To detect protein carbonyl as oxidative stress marker in Type 2 Diabetes Mellitus (T2DM). Materials and Methods: The present cross-sectional study was conducted on 100 subjects (aged 40 to 70 years) out of which 50 were T2DM and 50 were normal individuals. Serum was tested for Fasting Blood Sugar (FBS) and Glycated Haemoglobin (HbA1c) and Protein Carbonyl Content (PCC). Serum PCC was measured by spectrophotometric DNPH (dinitrophenylhydrazone) method of Reznick AZ and Packer L. Results: The protein carbonyl content, Fasting blood sugar and HbA1c were observed as positively correlated in type 2 diabetes mellitus as the levels of PCC, FBS and HbA1c were raised in T2DM as compared to controls. Conclusion: Increased HbA1c may be associated with generation of oxygen free radicals in the form of protein carbonyls and decreased antioxidants in T2DM.
The technique of peroral pneumocolon (POPC) has been found to be simple and easy to obtain excellent double contrast visualization of the distal ileum and proximal colon. Thirty-four patients were subjected to the POPC examination of which 29 had undergone prior barium meal follow through studies. In 86.2% of these cases POPC was found to be superior as compared to conventional studies. In 5 patients who could not retain Ba-enema, POPC was performed as first line of investigation with 100% efficacy.
Introduction: Metabolic Syndrome (MetS) is a condition that increases the risk of cardiac disease, diabetes, hypertension and may be associated with microalbuminuria. Aim: To investigate the prevalence of metabolic syndrome and to determine albumin to creatinine ratio as a predictor of cardiovascular disease in metabolic syndrome. Materials and Methods: This was a hospital based cross-sectional study conducted from February 2019 to January 2020 in the Department of Biochemistry and Outpatient Department of Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh. Out of enrolled 795 subjects, 452 were male and 343 were female. The prevalence of metabolic syndrome was calculated on the basis of metabolic syndrome criteria. Anthropometric parameters like age, weight, height, blood pressure and the biochemical parameters including fasting blood sugar, triglyceride, Lipid Accumulation Product (LAP), urinary albumin, serum creatinine and urinary Albumin to Creatinine Ratio were measured in study population. SPSS version 16 was used for statistical analysis and student independent sample t-test was used for comparing differences amongst the variables. A p-value less than 0.05 was considered as statistically significant. Results: Out of 795 subjects, 152 patients (19.12%) were hypertensive, 85 patients (10.69%) were diabetic and 29 patients (3.65%) were hypertensive with diabetic. The prevalence of metabolic syndrome was around 18.11% (144 subjects), out of which 52.78% were female and 47.22% were male. Out of 144 Metabolic Syndrome subjects, 23 subjects were diabetic, 32 were hypertensive, 14 were diabetic with hypertensive and 75 were others. The mean levels of urinary albumin creatinine ratio were increased significantly in metabolic syndrome subjects and the increase in urine Albumin to Creatinine Ratio (uACR) was more in metabolic syndrome subjects having Diabetes and Hypertension both. Conclusion: The present study concluded that the microalbuminuria is associated with metabolic syndrome. The microalbuminuria was found to be more significant in metabolic syndrome subjects who were diabetic with hypertensive as compared to diabetic or hypertensive alone.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.